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Am J Physiol Gastrointest Liver Physiol 274: G971-G977, 1998;
0193-1857/98 $5.00
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Vol. 274, Issue 6, G971-G977, June 1998

THEMES
G Protein-Coupled Receptors in Gastrointestinal Physiology
III. Asymmetry in plasma membrane signal transduction: lessons from brush-border Na+/H+ exchangers*

M. Donowitz, S. Khurana, C. M. Tse, and C. H. C. Yun

Departments of Medicine and Physiology, Gastrointestinal Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Signal transduction in epithelial cells adds another level of complexity to the signaling that occurs in symmetrical cells, in the form of the need to coordinate and keep separate signals at the apical and basolateral membranes. Regulation by protein kinases of ileal NaCl absorption and its component brush-border Na+/H+ exchanger are used as an example of how signaling in epithelial cells must deal with spatial localization of signals, protein-protein interactions, signaling molecules, and the involvement of the transport protein being regulated in collecting and focusing the signals generated at the receptor and beyond.

intestinal epithelial cells; epidermal growth factor; carbachol; NHE3; signalosomes

* Third in a series of invited articles on G Protein-Coupled Receptors in Gastrointestinal Physiology.




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