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Am J Physiol Gastrointest Liver Physiol 275: G8-G13, 1998;
0193-1857/98 $5.00
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Vol. 275, Issue 1, G8-G13, July 1998

THEMES
Neural Injury, Repair, and Adaptation in the GI Tract
II. The elusive action of capsaicin on the vagus nerve*

Peter Holzer

Department of Experimental and Clinical Pharmacology, University of Graz, A-8010 Graz, Austria

Capsaicin is an excitotoxin for primary afferent neurons, and perivagal administration of capsaicin is frequently used to ablate afferent fibers from the vagus nerve in an attempt to elucidate the role of afferent fibers in gastrointestinal (GI) regulation. However, this method has recently been called into question by research demonstrating that the molecular target of capsaicin on spinal and trigeminal afferents, vanilloid receptor subtype 1 (VR1), is absent from vagal afferents. Although some concerns about selectivity exist, the available information suggests that perineural capsaicin defunctionalizes afferent neurons of the vagus nerve by acting on a vanilloid receptor subtype that is structurally different from VR1.

vanilloid receptors; vanilloid receptor heterogeneity; excitotoxicity; vagal afferents; spinal afferents

*  Second in a series of invited articles on Neural Injury, Repair, and Adaptation in the GI Tract.




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