| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden
Neurokinin A (NKA) induces duodenal motility and increases mucosal permeability and bicarbonate secretion in the in situ perfused duodenum in anesthetized rats. In the present study, the NKA-induced increase in mucosal permeability was potentiated by luminal perfusion with lidocaine and diminished by vasoactive intestinal peptide (VIP) but unaltered by elevated intraluminal pressure. Elevation of intraluminal pressure, however, potentiated the stimulatory effect of NKA on bicarbonate secretion. In contrast, the tachykinin decreased the rate of alkalinization in rats subjected to elevated intraluminal pressure and treated with indomethacin. Similarly, NKA partially inhibited the VIP-stimulated bicarbonate secretion. Luminal lidocaine did not affect the secretory response to NKA. The motility induced by NKA was unaffected by VIP or lidocaine but decreased by elevated intraluminal pressure. It is concluded that the NKA-induced increase in duodenal mucosal bicarbonate secretion is independent of neurons and possibly mediated by prostanoids. The increase in mucosal permeability in response to NKA may be suppressed by mucosal nerves, perhaps utilizing VIP as one of the transmitters.
bicarbonate; duodenum; motility; permeability; tachykinin
This article has been cited by other articles:
|
|
 |
|
  A. Allen and G. Flemstrom Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin Am J Physiol Cell Physiol, January 1, 2005; 288(1): C1 - C19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Neunlist, F. Toumi, T. Oreschkova, M. Denis, J. Leborgne, C. L. Laboisse, J.-P. Galmiche, and A. Jarry Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G1028 - G1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, F. Shang, I. Markus, and E. Burcher Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 627 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nylander, A. Hallgren, and M. Sababi COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1169 - G1178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. ESFANDYARI, W. K. MACNAUGHTON, R. QUIRION, S. ST. PIERRE, J.-L. JUNIEN, and K. A. SHARKEY A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis FASEB J, July 1, 2000; 14(10): 1439 - 1446. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
