AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 275: G183-G186, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pachnis, V.
Right arrow Articles by Natarajan, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pachnis, V.
Right arrow Articles by Natarajan, D.
Vol. 275, Issue 2, G183-G186, August 1998

THEMES
Neural Injury, Repair, and Adaptation in the GI Tract
III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system*

V. Pachnis, P. Durbec, S. Taraviras, M. Grigoriou, and D. Natarajan

Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom

The enteric nervous system (ENS) in vertebrates is derived from the neural crest and constitutes the most complex part of the peripheral nervous system. Natural and induced mutagenesis in mammals has shown that the tyrosine kinase receptor RET and its functional ligand glial cell line-derived neurotrophic factor (GDNF) play key roles in the development of the ENS in humans and mice. We have developed and briefly describe here a number of assays that analyze the specific function of the RET receptor and its ligand. Our data suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.

RET tyrosine kinase receptor; glial cell line-derived neurotrophic factor; enteric nervous system

*  Third in a series of invited articles on Neural Injury, Repair, and Adaptation in the GI Tract.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. K. Sarna
Are interstitial cells of Cajal plurifunction cells in the gut?
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G372 - G390.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Farrugia, S. Lei, X. Lin, S. M. Miller, K. A. Nath, C. D. Ferris, M. Levitt, and J. H. Szurszewski
A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract
PNAS, July 8, 2003; 100(14): 8567 - 8570.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Sachs, H. Brohmann, D. Zechner, T. Muller, J. Hulsken, I. Walther, U. Schaeper, C. Birchmeier, and W. Birchmeier
Essential Role of Gab1 for Signaling by the c-Met Receptor In Vivo
J. Cell Biol., September 18, 2000; 150(6): 1375 - 1384.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online