AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 275: G314-G321, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thumshirn, M.
Right arrow Articles by Kammer, P. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thumshirn, M.
Right arrow Articles by Kammer, P. P.
Vol. 275, Issue 2, G314-G321, August 1998

Gastric mechanosensory and lower esophageal sphincter function in rumination syndrome

Miriam Thumshirn1, Michael Camilleri1, Russell B. Hanson1, Donald E. Williams2, Alfred J. Schei1, and Patricia P. Kammer1

1 Gastroenterology Research Unit and 2 Section of Behavioral Medicine, Mayo Foundation, Rochester, Minnesota 55905

Our hypothesis was that rumination syndrome is associated with gastric sensory and motor dysfunction. We studied gastric and somatic sensitivity, reflex relaxation of the lower esophageal sphincter (LES), and gastric compliance and accommodation postprandially and postglucagon. A barostatically controlled gastric bag and esophageal manometry were used to compare gastric sensorimotor functions and LES relaxation to gastric distension in 12 patients with rumination syndrome and 12 controls. During bag distensions, patients had greater nausea, bloating, and aggregate score, but not pain, compared with controls (P < 0.05). At 4 and 8 mmHg gastric distension, LES tone reduction was greater in patients than in controls (P < 0.05). Gastric compliance, accommodation to a standard meal, and response to glucagon were not different in patients and controls; however, 6 of 12 patients had no gastric accommodation; the latter patients had significantly greater pain perception during distension (P < 0.05) but normal somatic sensitivity compared with healthy controls. Rumination syndrome is characterized by higher gastric sensitivity and LES relaxation during gastric distension. A subgroup of patients also had absent postprandial accommodation.

lower esophageal sphincter relaxation; gastric tone; motility; sensation; barostat; Dent sleeve; accommodation; glucagon; cold stress


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Sun and J. D. Z. Chen
Gastric electrical stimulation inhibits postprandial antral tone partially via nitrergic pathway in conscious dogs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R904 - R908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Xue, G. R. Locke, M. Camilleri, J. A. J. Schuurkes, A. Meulemans, B. J. Coulie, J. H. Szurszewski, and G. Farrugia
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry
Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G74 - G82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. J. Chial, M. Camilleri, D. Burton, G. Thomforde, K. W. Olden, and D. Stephens
Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health
Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G130 - G137.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
H. J. Chial, M. Camilleri, D. E. Williams, K. Litzinger, and J. Perrault
Rumination Syndrome in Children and Adolescents: Diagnosis, Treatment, and Prognosis
Pediatrics, January 1, 2003; 111(1): 158 - 162.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
E P Bouras, S Delgado-Aros, M Camilleri, E J Castillo, D D Burton, G M Thomforde, and H J Chial
SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication
Gut, December 1, 2002; 51(6): 781 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. W. Mundt, T. Hausken, and M. Samsom
Effect of intragastric barostat bag on proximal and distal gastric accommodation in response to liquid meal
Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G681 - G686.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S D Kuiken, M Vergeer, S H Heisterkamp, G N J Tytgat, and G E E Boeckxstaens
Role of nitric oxide in gastric motor and sensory functions in healthy subjects
Gut, August 1, 2002; 51(2): 212 - 218.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
W Schwizer, A Steingotter, M Fox, T Zur, M Thumshirn, P Bosiger, and M Fried
Non-invasive measurement of gastric accommodation in humans
Gut, July 1, 2002; 51(90001): i59 - 62.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. D. Kuiken, M. Samsom, M. Camilleri, B. P. Mullan, D. D. Burton, L. J. Kost, T. J. Hardyman, B. H. Brinkmann, and M. K. O'connor
Development of a test to measure gastric accommodation in humans
Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1217 - G1221.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online