AJP - GI Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 275: G381-G386, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huizinga, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huizinga, J. D.
Vol. 275, Issue 3, G381-G386, September 1998

THEMES
Neural Injury, Repair, and Adaptation in the GI Tract
IV. Pathophysiology of GI motility related to interstitial cells of Cajal*

Jan D. Huizinga

Intestinal Disease Research Program and Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5

Our understanding of the physiological roles played by interstitial cells of Cajal (ICC) in relation to gastrointestinal (GI) motility is still rudimentary. Nevertheless, studies into the pathophysiology of ICC are emerging at a rapid pace. Caution should be exercised, however, in assuming correlations between changes in Kit immunoreactivity, findings of ultrastructural abnormalities in ICC, and the pathophysiology and symptoms of the patients. Recent studies have revealed reduced numbers or the absence of ICC in small intestine and colon that do not exhibit normal peristaltic activity. Furthermore, important evidence is emerging that motor abnormalities in newborns may be associated with delayed maturation of the ICC network. These preliminary clinical studies provide plausible hypotheses toward the pathophysiology of certain motor disorders and strongly encourage basic scientific studies directed toward discovering the intrinsic properties of ICC as well as obtaining a deeper understanding of the physiological roles played by these cells.

intestinal motility; pseudo-obstruction; motility disorders; development; injury; inflammation

* Fourth in a series of invited articles on Neural Injury, Repair, and Adaptation in the GI Tract.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. S. Zuckerbraun, L. E. Otterbein, P. Boyle, R. Jaffe, J. Upperman, R. Zamora, and H. R. Ford
Carbon monoxide protects against the development of experimental necrotizing enterocolitis
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G607 - G613.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
X.-Y. Wang, I. Berezin, H. B. Mikkelsen, T. Der, P. Bercik, S. M. Collins, and J. D. Huizina
Pathology of Interstitial Cells of Cajal in Relation to Inflammation Revealed by Ultrastructure But Not Immunohistochemistry
Am. J. Pathol., April 1, 2002; 160(4): 1529 - 1540.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. E. Daniel
Physiology and Pathophysiology of the Interstitial Cell of Cajal: From Bench to Bedside: III. Interaction of interstitial cells of Cajal with neuromediators: an interim assessment
Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1329 - G1332.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
M S Faussone-Pellegrini, P Fociani, R Buffa, and G Basilisco
Loss of interstitial cells and a fibromuscular layer on the luminal side of the colonic circular muscle presenting as megacolon in an adult patient
Gut, November 1, 1999; 45(5): 775 - 779.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. W. Powell, R. C. Mifflin, J. D. Valentich, S. E. Crowe, J. I. Saada, and A. B. West
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
Am J Physiol Cell Physiol, August 1, 1999; 277(2): C183 - C201.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online