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Am J Physiol Gastrointest Liver Physiol 275: G425-G432, 1998;
0193-1857/98 $5.00
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Vol. 275, Issue 3, G425-G432, September 1998

Bacteria rapidly colonize and modulate healing of gastric ulcers in rats

Susan N. Elliott1, André Buret2, Webb McKnight1, Mark J. S. Miller3, and John L. Wallace1

Departments of 1 Pharmacology and Therapeutics and 2 Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 4N1; and 3 Department of Pediatrics, Louisiana State University Medical Center, New Orleans, Louisiana 70112-2822

The stomach is generally regarded as an environment that is not conducive to bacterial colonization. In this study, we examined the possibility that this changes significantly when an ulcer has formed and that colonization of ulcers interferes with the normal healing process. Gastric ulcers were induced by serosal application of acetic acid. The relationship between ulcer healing and bacterial colonization was examined. The effects of antibiotics, induction of Lactobacillus colonization, and selective colonization with an antibiotic resistant strain of Escherichia coli on ulcer healing were examined. Within 6-12 h of their induction, gastric ulcers were colonized by a variety of bacteria, with gram-negative bacteria predominating. Suppression of colonization with antibiotics resulted in marked acceleration of healing. Induction of Lactobacillus colonization also accelerated ulcer healing. The beneficial effects of antibiotics were reversed through selective colonization with antibiotic-resistant E. coli. Bacterial colonization occurred irrespective of the method used to induce the ulcer. This study demonstrates that colonization of gastric ulcers in rats occurs rapidly and significantly impairs ulcer healing. This effect appeared to be primarily attributable to gram-negative bacteria.

acid secretion


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