AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 275: G521-G525, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shaker, R.
Right arrow Articles by Lang, I. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shaker, R.
Right arrow Articles by Lang, I. M.
Vol. 275, Issue 3, G521-G525, September 1998

Pharyngoglottal closure reflex: identification and characterization in a feline model

Reza Shaker, Bidyut K. Medda, Junlong Ren, Safwan Jaradeh, Pengyan Xie, and Ivan M. Lang

Medical College of Wisconsin Dysphagia Institute, and Division of Gastroenterology and Hepatology, Departments of Medicine, Neurology, and Otolaryngology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226

Earlier studies in humans have shown that pharyngeal stimulation by water at a threshold volume induces a brief vocal cord adduction, i.e., pharyngoglottal closure reflex. The present study was undertaken to 1) develop a suitable animal model for physiological studies of this reflex and 2) delineate its neural pathway and effector organs. Studies were done in cats by concurrent videoendoscopy and manometry followed by electromyographic studies. At a threshold volume (0.3 ± 0.06 ml), injection of water into the pharynx resulted in a brief closure of the vocal folds, closing the introitus to the trachea. Duration of this closure averaged 1.1 ± 0.1 s. Bilateral transection of the glossopharyngeal nerve completely abolished this reflex but not swallows induced by pharyngeal water stimulation. The pharyngoglottal closure reflex is present in the cats. The glossopharyngeal nerve is the afferent pathway of this reflex, and the interarytenoid and lateral cricoarytenoid muscles are among its target organs.

airway protection; gastroesophageal reflux


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Perera, M. Kern, C. Hofmann, L. Tatro, K. Chai, S. Kuribayashi, A. Lawal, and R. Shaker
Manometric evidence for a phonation-induced UES contractile reflex
Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G885 - G891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. K. Medda, M. Kern, J. Ren, P. Xie, S. O. Ulualp, I. M. Lang, and R. Shaker
Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing
Am J Physiol Gastrointest Liver Physiol, June 1, 2003; 284(6): G933 - G939.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online