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1 Department of Surgery, Louisiana State University Medical Center, Shreveport, Louisiana 71130; 2 Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267; and 3 Konar Center for Digestive and Liver Diseases, University of Rochester Medical Center, Rochester, New York 14646
We tested whether exogenous peptide YY (PYY) can
stimulate synthesis and lymphatic secretion of intestinal
apolipoprotein AIV (apo AIV). Rats with mesenteric lymph fistulas and
right atrial cannulas were given continuous intravenous infusions of
control vehicle or PYY at 25, 50, 75, 100, or 200 pmol · kg
1 · h1.
PYY (75-200
pmol · kg1 · h1)
stimulated lymphatic apo AIV output from 1.5- to 3.5-fold higher than
basal output. In separate experiments, PYY (100 pmol · kg1 · h1)
produced a 60% increase in jejunal mucosal apo AIV synthesis but had
no effect on mucosal apo AIV mRNA levels at doses up to 200 pmol · kg1 · h1.
Finally, exogenous PYY infusion (100 pmol · kg1 · h1)
produced a plasma PYY increment of 30 pM compared with an increment of
18.7 pM in response to ileal infusion of lipid. These results support
the hypothesis that PYY may be an endocrine mediator of the effects of
distal gut lipid on production and release of intestinal apo AIV,
likely via a posttranscriptional mechanism of action.
ileal brake; lipid; nutrient absorption; chylomicrons; gastrointestinal hormones
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