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Am J Physiol Gastrointest Liver Physiol 275: G1193-G1201, 1998;
0193-1857/98 $5.00
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Vol. 275, Issue 5, G1193-G1201, November 1998

A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs

Naohiro Furukawa1, Hiroyuki Fukuda1, Mizue Hatano1, Tomoshige Koga1, and Yasuteru Shiroshita2

1 Department of Physiology, Kawasaki Medical School, Kurashiki 701-01; and 2 Section I, Pharmacology Department, Research Division, Tsukuba Research Laboratories, Nippon Glaxo, Tsukuba 300-42, Japan

The roles of tachykinin neurokinin-1 (NK1) receptors in the induction of fictive retching, hypersalivation, and gastric responses associated with emesis induced by abdominal vagal stimulation were studied in paralyzed, decerebrated dogs. Vagal stimulation induced gradual increases in salivary secretion and activity of the parasympathetic postganglionic fibers to the submandibular gland, relaxation of the gastric corpus and antrum, and fictive retching. However, hypersalivation and increased nerve activity were suppressed and antral contractility was enhanced during fictive retching. An NK1 receptor antagonist, GR-205171, abolished the enhancement of antral contractility and fictive retching but had no effect on corpus and antral relaxation. Hypersalivation and increased nerve activity were inhibited by GR-205171 but were not completely abolished. Reflex salivation by lingual nerve stimulation was unaffected. These results suggest that GR-205171 acts on the afferent pathway in the bulb and diminishes hypersalivation and antral contraction related to emesis as well as fictive retching but does not affect gastric relaxation or hypersalivation induced by the vagovagal, vagosalivary, and linguosalivary reflexes.

retching; substance P; chorda tympani; linguosalivary reflex


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