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Am J Physiol Gastrointest Liver Physiol 275: G879-G882, 1998;
0193-1857/98 $5.00
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Vol. 275, Issue 5, G879-G882, November 1998

THEMES
Genetic Disorders of Membrane Transport
I. Glucose Galactose Malabsorption*

Ernest M. Wright

Physiology Department, University of California School of Medicine, Los Angeles, California 90095-1751

Glucose Galactose Malabsorption is a genetic disorder caused by a defect in glucose and galactose transport across the intestinal brush border. Normally, lactose in milk is broken down into glucose and galactose by lactase, an ectoenzyme on the brush border, and the hexoses are transported into the cell by the Na+-glucose cotransporter SGLT1. The mutations causing the defect in sugar transport have been identified in patients from 33 kindreds, and functional studies have established how these mutations cause the disease.

sodium-glucose cotransporter; genetic disease; protein trafficking

*  First in a series of invited articles on Genetic Disorders of Membrane Transport.




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