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1 Department of
Gastrointestinal Surgery C,
Glucagon-like peptide (GLP)-1 inhibits acid
secretion and gastric emptying in humans, but the effect on acid
secretion is lost after vagotomy. To elucidate the mechanism involved,
we studied its effect on vagally stimulated gastropancreatic secretion
and motility in urethan-anesthetized pigs with cut splanchnic nerves, in which insulin-induced hypoglycemia elicited a marked stimulation of
gastropancreatic secretion and antral motility. In addition, we studied
vagally stimulated motility and pancreatic secretion in isolated
perfused preparations of the porcine antrum and pancreas. GLP-1
infusion (2 pmol · kg
1 · min1)
strongly and significantly inhibited hypoglycemia-induced antral motility, gastric acid secretion, pancreatic bicarbonate and protein secretion, and pancreatic polypeptide (PP) secretion. GLP-1 (at 1010-108
mol/l) did not inhibit vagally induced antral motility, pancreatic exocrine secretion, or gastrin and PP secretion in isolated perfused antrum and pancreas. We conclude that the inhibitory effect of peripheral GLP-1 on upper gastrointestinal secretion and motility is
exerted via interaction with centers in the brain or afferent neural
pathways relaying to the vagal motor nuclei.
acid secretion; gastrin; pancreatic polypeptide; hypoglycemia; neuroglucopenia; enterogastrone; ileal brake; gastrointestinal effects
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