AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 275: G1317-G1323, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vieira-Coelho, M. A.
Right arrow Articles by Bertorello, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vieira-Coelho, M. A.
Right arrow Articles by Bertorello, A. M.
Vol. 275, Issue 6, G1317-G1323, December 1998

Dopamine-dependent inhibition of jejunal Na+-K+-ATPase during high-salt diet in young but not in adult rats

M. Augusta Vieira-Coelho, Vera A. Lucas Teixeira, Yigael Finkel, Patricio Soares-Da-Silva, and Alejandro M. Bertorello

Departments of Molecular Medicine and Woman and Child Health, Karolinska Institute, Karolinska Hospital, 171 76 Stockholm, Sweden; and Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal

During high-salt diet endogenous dopamine (DA) reduces jejunal sodium transport in young but not in adult rats. This study was designed to evaluate whether this effect is mediated, at the cellular level, by inhibition of Na+-K+-ATPase activity. Enzyme activity was determined in isolated jejunal cells by the rate of [gamma -32P]ATP hydrolysis. Cells were obtained from weanling and adult rats fed either with high- or normal-salt diet. In 20-day-old but not in 40-day-old rats Na+-K+-ATPase activity was significantly reduced during high-salt diet. This inhibition was abolished by a blocker of DA synthesis. The decreased activity was associated with a decreased alpha 1-subunit at the plasma membrane. During high-salt diet there was an increase in DA content in jejunal cells from 20-day-old rats, associated with a parallel decrease in 5-hydroxytryptamine, compared with normal-salt diet. In 40-day-old rats, however, the catecholamine level remained unchanged during high-salt diet. Incubation of isolated jejunal cells with DA resulted in a dose-dependent inhibition of Na+-K+-ATPase activity in 20- but not in 40-day-old rats. We conclude that during high-salt diet, jejunal Na+-K+-ATPase in 20-day-old rats is inhibited, and this effect is likely to be mediated by locally formed DA.

sodium-potassium-adenosinetriphosphatase synthesis; serotonin; L-3,4-dihydroxyphenylalanine


This article has been cited by other articles:


Home page
 J EndocrinolHome page
A. J Lopez-Contreras, J. D Galindo, C. Lopez-Garcia, M. T Castells, A. Cremades, and R. Penafiel
Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice
J. Endocrinol., March 1, 2008; 196(3): 615 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose
Functional genomics of the dopaminergic system in hypertension
Physiol Genomics, November 17, 2004; 19(3): 233 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Pizzinat, S. Marchal-Victorion, A. Maurel, C. Ordener, G. Bompart, and A. Parini
Substrate-dependent regulation of MAO-A in rat mesangial cells: involvement of dopamine D2-like receptors
Am J Physiol Renal Physiol, January 1, 2003; 284(1): F167 - F174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. A. Vieira-Coelho, P. Serrao, J. T. Guimaraes, M. Pestana, and P. Soares-Da-Silva
Concerted action of dopamine on renal and intestinal Na+-K+-ATPase in the rat remnant kidney
Am J Physiol Renal Physiol, December 1, 2000; 279(6): F1033 - F1044.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. Pacha
Development of Intestinal Transport Function in Mammals
Physiol Rev, October 1, 2000; 80(4): 1633 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. Lucas-Teixeira, M. A. Vieira-Coelho, M. P. Serrão, and P. Soares-da-Silva
Food Deprivation Increases {alpha}2-Adrenoceptor-Mediated Modulation of Jejunal Epithelial Transport in Young and Adult Rats
J. Nutr., October 1, 2000; 130(10): 2461 - 2466.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. G. Therien and R. Blostein
Mechanisms of sodium pump regulation
Am J Physiol Cell Physiol, September 1, 2000; 279(3): C541 - C566.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. Lucas-Teixeira, M. A. Vieira-Coelho, and P. Soares-da-Silva
Food Intake Abolishes the Response of Rat Jejunal Na+,K+-ATPase to Dopamine
J. Nutr., April 1, 2000; 130(4): 877 - 881.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Ogimoto, G. A. Yudowski, C. J. Barker, M. Kohler, A. I. Katz, E. Feraille, C. H. Pedemonte, P.-O. Berggren, and A. M. Bertorello
G protein-coupled receptors regulate Na+,K+-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin
PNAS, March 28, 2000; 97(7): 3242 - 3247.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. A. Yudowski, R. Efendiev, C. H. Pedemonte, A. I. Katz, P.-O. Berggren, and A. M. Bertorello
Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+,K+-ATPase alpha subunit and regulates its trafficking
PNAS, June 6, 2000; 97(12): 6556 - 6561.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. M. Ridge, L. Dada, E. Lecuona, A. M. Bertorello, A. I. Katz, D. Mochly-Rosen, and J. I. Sznajder
Dopamine-induced Exocytosis of Na,K-ATPase Is Dependent on Activation of Protein Kinase C-epsilon and -delta
Mol. Biol. Cell, April 1, 2002; 13(4): 1381 - 1389.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online