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Am J Physiol Gastrointest Liver Physiol 276: G37-G42, 1999;
0193-1857/99 $5.00
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Vol. 276, Issue 1, G37-G42, January 1999

Effect of insulin-like growth factor I on in vivo intestinal absorption of D-galactose in cirrhotic rats

Inma Castilla-Cortázar1, Antonio Picardi1,2, Alicia Tosar1, Juan Ainzúa1, Elena Urdaneta1, María García1, María Pascual1, Jorge Quiroga3, and Jesús Prieto3

Departments of 1 Human Physiology and 3 Internal Medicine, Liver Unit, School of Medicine, University of Navarra, 31080 Pamplona, Spain; and 2 Department of Internal Medicine, Biomedical Campus, Libero Istituto Universitario, 00155 Rome, Italy

Insulin-like growth factor I (IGF-I) bioavailability is reduced in liver cirrhosis, a condition frequently associated with malnutrition. We have analyzed in vivo absorption of D-galactose by jejunal loops in rats with CCl4-induced liver cirrhosis and the influence of IGF-I on intestinal sugar transport in this disease. Two different study protocols were followed. In protocol 1, healthy control rats or cirrhotic rats received saline or IGF-I (2 µg · 100 g body wt-1 · day-1) for 2 wk. In protocol 2, control and cirrhotic rats received saline or IGF-I as a bolus injection of 1 µg/100 g body wt followed by continuous infusion of the same dose for 100 min. In vivo D-galactose absorption was reduced in cirrhotic rats compared with healthy controls. IGF-I, as both a chronic (protocol 1) and acute treatment (protocol 2), was able to improve sugar transport in cirrhotic rats but had no effect on sugar absorption in healthy rats. A significant elongation of enterocyte microvilli was observed in cirrhotic animals; this alteration was totally or partially corrected by chronic or acute IGF-I administration. Our results show that in vivo jejunal sugar transport and microvilli structure are altered in liver cirrhosis and that IGF-I, among other effects, may correct these changes by modulating cytoskeletal organization in enterocytes.

liver cirrhosis; malnutrition; malabsorption; glucose and galactose transport; microvilli


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M. Pascual, I. Castilla-Cortazar, E. Urdaneta, J. Quiroga, M. Garcia, A. Picardi, and J. Prieto
Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-I
Am J Physiol Gastrointest Liver Physiol, August 1, 2000; 279(2): G319 - G324.
[Abstract] [Full Text] [PDF]


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