AJP - GI Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 276: G79-G91, 1999;
0193-1857/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Drucker, D. J.
Right arrow Articles by Brubaker, P. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Drucker, D. J.
Right arrow Articles by Brubaker, P. L.
Vol. 276, Issue 1, G79-G91, January 1999

Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis

Daniel J. Drucker1, Bernardo Yusta1, Robin P. Boushey1, Lorraine DeForest1, and Patricia L. Brubaker1,2

1 Department of Medicine, Banting and Best Diabetes Centre, The Toronto Hospital, and 2 Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G 2C4

The pathology of Crohn's disease and ulcerative colitis is characterized by chronic inflammation and destruction of the gastrointestinal epithelium. Although suppression of inflammatory mediators remains the principle component of current disease therapeutics, strategies for enhancing repair and regeneration of the compromised intestinal epithelium have not been widely explored. The demonstration that a peptide hormone secreted by the intestinal epithelium, glucagon-like peptide-2 (GLP-2), is a potent endogenous stimulator of intestinal epithelial proliferation in the small bowel prompted studies of the therapeutic efficacy of GLP-2 in CD1 and BALB/c mice with dextran sulfate (DS)-induced colitis. We report here that a human GLP-2 analog (h[Gly2]GLP-2) significantly reverses weight loss, reduces interleukin-1 expression, and increases colon length, crypt depth, and both mucosal area and integrity in the colon of mice with acute DS colitis. The effects of h[Gly2]GLP-2 in the colon are mediated in part via enhanced stimulation of mucosal epithelial cell proliferation. These observations suggest that exploitation of the normal mechanisms used to regulate intestinal proliferation may be a useful adjunct for healing mucosal epithelium in the presence of active intestinal inflammation.

intestine; inflammatory bowel disease; epithelium; growth factor; inflammation


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. L. Sigalet, L. E. Wallace, J. J. Holst, G. R. Martin, T. Kaji, H. Tanaka, and K. A. Sharkey
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G211 - G221.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J. R O'Hara, A. E Lomax, G. M Mawe, and K. A Sharkey
Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon
Gut, February 1, 2007; 56(2): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. E. Lomax, J. R. O'Hara, N. P. Hyland, G. M. Mawe, and K. A. Sharkey
Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G482 - G491.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
E. M Sinclair and D. J. Drucker
Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential
Physiology, October 1, 2005; 20(5): 357 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. R. O'Hara, W. Ho, D. R. Linden, G. M. Mawe, and K. A. Sharkey
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis
Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G998 - G1007.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. L. Cameron, P.-C. Yang, and M. H. Perdue
Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy
Am J Physiol Gastrointest Liver Physiol, June 1, 2003; 284(6): G905 - G912.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
K. E. Mayo, L. J. Miller, D. Bataille, S. Dalle, B. Goke, B. Thorens, and D. J. Drucker
International Union of Pharmacology. XXXV. The Glucagon Receptor Family
Pharmacol. Rev., March 1, 2003; 55(1): 167 - 194.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
D J Drucker
Gut adaptation and the glucagon-like peptides
Gut, March 1, 2002; 50(3): 428 - 435.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. P. Boushey, B. Yusta, and D. J. Drucker
Glucagon-like Peptide (GLP)-2 Reduces Chemotherapy-associated Mortality and Enhances Cell Survival in Cells Expressing a Transfected GLP-2 Receptor
Cancer Res., January 1, 2001; 61(2): 687 - 693.
[Abstract] [Full Text]

Home page
 GutHome page
M A Benjamin, D M McKay, P-C Yang, H Cameron, and M H Perdue
Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse
Gut, July 1, 2000; 47(1): 112 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Tavares, D. J. Drucker, and P. L. Brubaker
Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats
Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E134 - E139.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Thulesen, B Hartmann, C Nielsen, J J Holst, and S S Poulsen
Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre
Gut, November 1, 1999; 45(5): 672 - 678.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. P. Boushey, B. Yusta, and D. J. Drucker
Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis
Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E937 - E947.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Yusta, R. Somwar, F. Wang, D. Munroe, S. Grinstein, A. Klip, and D. J. Drucker
Identification of Glucagon-like Peptide-2 (GLP-2)-activated Signaling Pathways in Baby Hamster Kidney Fibroblasts Expressing the Rat GLP-2 Receptor
J. Biol. Chem., October 22, 1999; 274(43): 30459 - 30467.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Yusta, R. P. Boushey, and D. J. Drucker
The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via a cAMP-dependent Protein Kinase-independent Pathway
J. Biol. Chem., November 3, 2000; 275(45): 35345 - 35352.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Lovshin, J. Estall, B. Yusta, T. J. Brown, and D. J. Drucker
Glucagon-like Peptide (GLP)-2 Action in the Murine Central Nervous System Is Enhanced by Elimination of GLP-1 Receptor Signaling
J. Biol. Chem., June 8, 2001; 276(24): 21489 - 21499.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Bjerknes and H. Cheng
Modulation of specific intestinal epithelial progenitors by enteric neurons
PNAS, October 23, 2001; 98(22): 12497 - 12502.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online