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Am J Physiol Gastrointest Liver Physiol 276: G518-G528, 1999;
0193-1857/99 $5.00
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Vol. 276, Issue 2, G518-G528, February 1999

Voltage sensitivity of slow wave frequency in isolated circular muscle strips from guinea pig gastric antrum

S.-M. Huang1, S. Nakayama1, S. Iino2, and T. Tomita3

Departments of 1 Physiology and 2 Anatomy, School of Medicine, Nagoya University, Nagoya 466-8550; and 3 Division of Smooth Muscle Research, Institute of Medical Sciences, Fujita Health University, Toyoake, Aichi 470-11, Japan

In circular muscle preparations isolated from the guinea pig gastric antrum, regular spontaneous electrical activity (slow waves) was recorded. Under normal conditions (6 mM K+), the frequency and shape of the slow waves were similar to those observed in ordinary stomach smooth muscle preparations. When the resting membrane potential was hyperpolarized and depolarized by changing the extracellular K+ concentration (2-18 mM), the frequency of slow waves decreased and increased, respectively. Application of cromakalim hyperpolarized the cell membrane and reduced the frequency of slow waves in a dose-dependent manner. Cromakalim (3 µM) hyperpolarized the membrane, and slow waves ceased in most preparations. In the presence of cromakalim, subsequent increases in the extracellular K+ concentration restored the frequency of slow waves accompanied by depolarization. Also, glibenclamide completely antagonized this effect of cromakalim. In smooth muscle strips containing both circular and longitudinal muscle layers, such changes in the slow wave frequency were not observed. It was concluded that the maneuver of isolating circular smooth muscle altered the voltage dependence of the slow wave frequency.

pacemaker; smooth muscle; voltage dependence; potassium channel opener


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