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Am J Physiol Gastrointest Liver Physiol 276: G901-G908, 1999;
0193-1857/99 $5.00
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Vol. 276, Issue 4, G901-G908, April 1999

Intracisternal TRH analog increases gastrin release and corpus histidine decarboxylase activity in rats

Min Song, Hong Yang, John H. Walsh, Gordon Ohning, Helen Wong, and Yvette Taché

CURE: Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California, Los Angeles, California 90073

Thyrotropin-releasing hormone (TRH) acts in brain stem nuclei to induce vagally mediated stimulation of gastric secretion. The effects of intracisternal injection of the TRH analog RX-77368 on plasma gastrin levels and corpus histidine decarboxylase (HDC) activity were studied in 48-h fasted conscious rats. RX-77368 (25-100 ng) increased plasma gastrin levels by threefold at 30 min, which remained significantly higher than control at 2 and 4 h postinjection. Corpus HDC activity began to increase at 2 h and reached a peak at 4 h postinjection with a 21-fold maximum response observed at 50 ng. Morphological changes in the appearance of corpus HDC-immunoreactive cells correlated well with HDC activity. Pretreatment with gastrin monoclonal antibody completely prevented RX-77368 stimulatory effects on HDC activity. Atropine significantly attenuated gastrin increase at 30 min by 26%. These results indicated that in conscious fasted rats, TRH analog acts in the brain to increase corpus HDC activity in the enterochromaffin-like cells, which involves gastrin release stimulated by central TRH analog.

enterochromaffin-like cell; gastrin monoclonal antibody; vagus; thyrotropin-releasing hormone


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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
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Am J Physiol Gastrointest Liver Physiol, October 1, 2001; 281(4): G997 - G1003.
[Abstract] [Full Text] [PDF]


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