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1 Combined Section of Pediatric
Gastroenterology and Nutrition,
Probiotic agents,
live microorganisms with beneficial effects for the host, may offer an
alternative to conventional antimicrobials in the treatment and
prevention of enteric infections. The probiotic agents
Lactobacillus plantarum 299v and
Lactobacillus rhamnosus GG
quantitatively inhibited the adherence of an attaching and effacing
pathogenic Escherichia coli to HT-29
intestinal epithelial cells but did not inhibit adherence to
nonintestinal HEp-2 cells. HT-29 cells were grown under conditions that
induced high levels of either MUC2 or MUC3 mRNA, but HEp-2 cells
expressed only minimal levels of MUC2 and no MUC3 mRNA. Media enriched
for MUC2 and MUC3 mucin were added exogenously to binding assays and
were shown to be capable of inhibiting enteropathogen adherence to
HEp-2 cells. Incubation of L. plantarum 299v with HT-29 cells increased MUC2 and MUC3
mRNA expression levels. From these in vitro studies, we propose the
hypothesis that the ability of probiotic agents to inhibit adherence of
attaching and effacing organisms to intestinal epithelial cells is
mediated through their ability to increase expression of MUC2 and MUC3
intestinal mucins.
MUC2; MUC3; Escherichia coli O157:H7; Lactobacillus plantarum; Lactobacillus rhamnosus
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