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Am J Physiol Gastrointest Liver Physiol 276: G1373-G1379, 1999;
0193-1857/99 $5.00
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Vol. 276, Issue 6, G1373-G1379, June 1999

ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle

L. Xue1, G. Farrugia1,2, M. G. Sarr3, and J. H. Szurszewski1,2

1 Department of Physiology and Biophysics, 2 Division of Gastroenterology and Hepatology, and 3 Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905

The neurotransmitter(s) that generates the fast component of the inhibitory junction potential (IJP-F) in human jejunal circular smooth muscle is not known. The aim of this study was to determine the role of ATP and purinergic receptors in the generation of the IJP-F in human jejunal circular smooth muscle strips. The P2-receptor antagonist suramin (100 µM) reduced the IJP-F by 28%. Apamin (1 µM) reduced the IJP-F by 25%. Desensitization of muscle strips with the putative P2x-receptor agonist alpha ,beta -methylene ATP (alpha ,beta -MeATP, 100 µM) decreased the IJP-F by 44%, and desensitization with the putative P2y-receptor agonist adenosine 5'-O-2-thiodiphosphate (ADPbeta S) completely abolished the IJP-F. Desensitization with the putative P2y-receptor agonist 2-methylthioATP had no effect on the IJP-F. Exogenous ATP evoked a hyperpolarization with a time course that matched the IJP-F. The ATP-evoked hyperpolarization was reduced by apamin and suramin, reduced by desensitization with alpha ,beta -MeATP (69% decrease), and abolished by desensitization with ADPbeta S. These data suggest that the IJP-F in human jejunal circular smooth muscle is mediated in part by ATP through an ADPbeta S-sensitive P2 receptor.

neurotransmission; microelectrodes; purinergic receptors


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