| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109
In this study, we used an in vivo anesthetized
rat model to investigate the mechanisms responsible for duodenal
acid-induced inhibition of gastric motility. Intraduodenal infusion of
HCl produced a rate-dependent decrease in intragastric pressure.
Infusion of HCl at 2 ml/h produced a physiological plasma secretin
level and elicited a decrease in intragastric pressure of 3.0 ± 0.2 cmH20. Infusion of rabbit secretin
antiserum reduced the acid-induced inhibition of gastric motility by 85 ± 5%, suggesting mediation mainly by endogenous secretin.
Administration of the cholecystokinin (CCK)-A antagonist MK-329 caused
only a modest 10 ± 3% reduction in gastric relaxation, whereas the
serotonin antagonist ICS-205930 had no effect. In contrast,
immunoneutralization with the secretin antibody caused only a 15%
reduction in the relaxation evoked by a higher rate of HCl infusion (3 ml/h), whereas MK-329 and ICS-205930 caused a 20 ± 4% reduction
and no reduction, respectively. Bilateral truncal vagotomy or perivagal
application of capsaicin completely abolished gastric relaxation in
response to low rates (1-2 ml/h) of 0.1 N HCl infusion but only
partially affected gastric relaxation in response to a higher infusion
rate (3 ml/h). These observations indicate that multiple pathways
mediate the duodenal acid-induced inhibition of gastric motility. At
low rates of HCl infusion, gastric relaxation is mediated primarily by
endogenous secretin, which acts through vagal afferent pathways. At
higher rates of HCl infusion, gastric relaxation is mediated by
endogenous secretin, CCK, and possibly by the direct action of HCl on
vagal afferent pathways or yet unidentified neuropathways.
vagal afferent; serotonin; secretin; cholecystokinin; duodenal acidification
This article has been cited by other articles:
|
|
 |
|
  Y. Li, X. Wu, H. Yao, and C. Owyang Secretin activates vagal primary afferent neurons in the rat: evidence from electrophysiological and immunohistochemical studies Am J Physiol Gastrointest Liver Physiol, October 1, 2005; 289(4): G745 - G752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Danzer, M. Jocic, C. Samberger, E. Painsipp, E. Bock, M.-A. Pabst, K. Crailsheim, R. Schicho, I. T. Lippe, and P. Holzer Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G403 - G411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-J. Lee, R. Vos, J. Janssens, and J. Tack Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans Am J Physiol Gastrointest Liver Physiol, February 1, 2004; 286(2): G278 - G284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li and C. Owyang Musings on the Wanderer: What's New in Our Understanding of Vago-Vagal Reflexes? V. Remodeling of vagus and enteric neural circuitry after vagal injury Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G461 - G469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Mundt, T. Hausken, and M. Samsom Effect of intragastric barostat bag on proximal and distal gastric accommodation in response to liquid meal Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G681 - G686. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
