AJP - GI Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 277: G48-G54, 1999;
0193-1857/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ko, S. B. H.
Right arrow Articles by Hayakawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ko, S. B. H.
Right arrow Articles by Hayakawa, T.
Vol. 277, Issue 1, G48-G54, July 1999

Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells

S. B. H. Ko1, S. Naruse1, M. Kitagawa1, H. Ishiguro1, M. Murakami2, and T. Hayakawa1

1 Internal Medicine II, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550; and 2 National Institute of Physiological Sciences, Okazaki 444-0867, Japan

The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced secretin-stimulated fluid secretion and increased the vascular resistance when the perfusion rate was held constant. In the isolated interlobular duct segments, AVP inhibited secretin-stimulated fluid secretion, indicating the direct inhibitory action of AVP on the duct cells. AVP affected neither the basal nor the secretin-induced cAMP productions, suggesting that AVP inhibits the fluid secretion at a point distal to the production of cAMP. AVP increased intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Ca2+. When [Ca2+]i was elevated by the application of thapsigargin, AVP caused a rapid decrease in [Ca2+]i. AVP seems to activate both Ca2+ release from intracellular stores and Ca2+ efflux across the plasma membrane, but its relation to the inhibition of fluid secretion remains to be clarified. It is concluded that AVP directly inhibits secretin-stimulated ductal fluid secretion in the guinea pig pancreas.

isolated vascularly perfused pancreas; isolated interlobular duct segment; luminal volume; adenosine 3',5'-cyclic monophosphate; intracellular calcium concentration


This article has been cited by other articles:


Home page
 J. Physiol.Home page
M. R. Dorwart, N. Shcheynikov, Y. Wang, S. Stippec, and S. Muallem
SLC26A9 is a Cl channel regulated by the WNK kinases
J. Physiol., October 1, 2007; 584(1): 333 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Hamada, H. Ishiguro, A. Yamamoto, S. Shimano-Futakuchi, S. B. H. Ko, T. Yoshikawa, H. Goto, M. Kitagawa, T. Hayakawa, Y. Seo, et al.
Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts
Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1431 - C1439.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Hegyi, Z. Rakonczay Jr., L. Tiszlavicz, A. Varro, A. Toth, G. Racz, G. Varga, M. A. Gray, and B. E. Argent
Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts
Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1030 - C1041.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. B. H. Ko, S. Naruse, M. Kitagawa, H. Ishiguro, S. Furuya, N. Mizuno, Y. Wang, T. Yoshikawa, A. Suzuki, S. Shimano, et al.
Aquaporins in rat pancreatic interlobular ducts
Am J Physiol Gastrointest Liver Physiol, February 1, 2002; 282(2): G324 - G331.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online