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Am J Physiol Gastrointest Liver Physiol 277: G48-G54, 1999;
0193-1857/99 $5.00
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Vol. 277, Issue 1, G48-G54, July 1999

Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells

S. B. H. Ko1, S. Naruse1, M. Kitagawa1, H. Ishiguro1, M. Murakami2, and T. Hayakawa1

1 Internal Medicine II, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550; and 2 National Institute of Physiological Sciences, Okazaki 444-0867, Japan

The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced secretin-stimulated fluid secretion and increased the vascular resistance when the perfusion rate was held constant. In the isolated interlobular duct segments, AVP inhibited secretin-stimulated fluid secretion, indicating the direct inhibitory action of AVP on the duct cells. AVP affected neither the basal nor the secretin-induced cAMP productions, suggesting that AVP inhibits the fluid secretion at a point distal to the production of cAMP. AVP increased intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Ca2+. When [Ca2+]i was elevated by the application of thapsigargin, AVP caused a rapid decrease in [Ca2+]i. AVP seems to activate both Ca2+ release from intracellular stores and Ca2+ efflux across the plasma membrane, but its relation to the inhibition of fluid secretion remains to be clarified. It is concluded that AVP directly inhibits secretin-stimulated ductal fluid secretion in the guinea pig pancreas.

isolated vascularly perfused pancreas; isolated interlobular duct segment; luminal volume; adenosine 3',5'-cyclic monophosphate; intracellular calcium concentration


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