| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Pathology and Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697-4800
The hypothesis that epithelial cells release
preformed antibiotic peptides as components of mucosal innate immunity
has gained experimental support in recent years. In the mammalian small
intestine, Paneth cells secrete granules that are rich in 
-defensins
and additional antimicrobial peptides into the lumen of the crypt. The
-defensins are homologues of peptides that function as mediators of
nonoxidative microbial cell killing in phagocytic leukocytes, and they
are potent microbicidal agents in in vitro assays. Because certain
mouse -defensins stimulate cultured epithelial cells to secrete
chloride ion, those peptides appear to be capable of interacting
directly with the apical membranes of neighboring cells and perhaps
influencing crypt physiology. In instances of crypt disruption or
induced Paneth cell deficiency, crypt intermediate cells appear to
compensate by accumulating and secreting Paneth cell antimicrobial
peptides. Challenges for the future will be to understand the
mechanisms of this epithelial plasticity and to show that Paneth cells
contribute directly to innate immunity in the crypt microenvironment.
innate immunity; crypt epithelium; cryptdins
This article has been cited by other articles:
|
|
 |
|
  G. Canny and S. P. Colgan Events at the Host-Microbial Interface of the Gastrointestinal Tract I. Adaptation to a microbial world: role of epithelial bactericidal/permeability-increasing protein Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G593 - G597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Toback, M. M. Walsh-Reitz, M. W. Musch, E. B. Chang, J. Del Valle, H. Ren, E. Huang, and T. E. Martin Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic Am J Physiol Gastrointest Liver Physiol, July 7, 2003; 285(2): G344 - G353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Canny, O. Levy, G. T. Furuta, S. Narravula-Alipati, R. B. Sisson, C. N. Serhan, and S. P. Colgan Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia PNAS, March 19, 2002; 99(6): 3902 - 3907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Tran, P. A. Tran, Y.-Q. Tang, J. Yuan, T. Cole, and M. E. Selsted Homodimeric theta -Defensins from Rhesus macaque Leukocytes. ISOLATION, SYNTHESIS, ANTIMICROBIAL ACTIVITIES, AND BACTERIAL BINDING PROPERTIES OF THE CYCLIC PEPTIDES J. Biol. Chem., January 25, 2002; 277(5): 3079 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. McGarvey and L. E. Bermudez Phenotypic and Genomic Analyses of the Mycobacterium avium Complex Reveal Differences in Gastrointestinal Invasion and Genomic Composition Infect. Immun., December 1, 2001; 69(12): 7242 - 7249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. O. Kisich, L. Heifets, M. Higgins, and G. Diamond Antimycobacterial Agent Based on mRNA Encoding Human {beta}-Defensin 2 Enables Primary Macrophages To Restrict Growth of Mycobacterium tuberculosis Infect. Immun., April 1, 2001; 69(4): 2692 - 2699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Merlin, G. Yue, W. I. Lencer, M. E. Selsted, and J. L. Madara Cryptdin-3 induces novel apical conductance(s) in Cl{-} secretory, including cystic fibrosis, epithelia Am J Physiol Cell Physiol, February 1, 2001; 280(2): C296 - C302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Putsep, L.-G. Axelsson, A. Boman, T. Midtvedt, S. Normark, H. G. Boman, and M. Andersson Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins J. Biol. Chem., December 15, 2000; 275(51): 40478 - 40482. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
