| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706
The effect of
orally administered insulin-like growth factor-I (IGF-I) on small
intestinal structure and function was studied in 5-day-old
colostrum-deprived piglets. Human recombinant IGF-I (3.5 mg · kg
1 · day1)
or control vehicle was given orogastrically for 4 days. Body weights,
jejunal and ileal mucosa wet and dry weights, and serum IGF-I levels
were similar in the two groups. Small intestinal villus height and
crypt depth and jejunal enterocyte microvillar dimensions were also
similar between groups. Oral IGF-I produced higher rates of jejunal ion
transport because of increased basal Na+ absorption. Short-circuit
current responses to mucosal addition of
D-glucose and
L-alanine and net
transepithelial absorption of
3-O-methylglucose were increased by
IGF-I. Carrier-mediated uptake of
D-glucose per milligram in
everted jejunal sleeves was greater in IGF-I-treated piglets because of
a significantly greater maximal rate of uptake. We conclude that rates
of net Na+ and
Na+-dependent nutrient absorption
are enhanced in piglets treated with oral IGF-I, and this effect is
independent of changes in mucosal mass or surface area.
growth factors; ion transport; insulin-like growth factor-I
This article has been cited by other articles:
|
|
 |
|
  C. Sandu, F. Artunc, M. Palmada, R. Rexhepaj, F. Grahammer, A. Hussain, C. Yun, D. R. Alessi, and F. Lang Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G868 - G876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Grahammer, G. Henke, C. Sandu, R. Rexhepaj, A. Hussain, B. Friedrich, T. Risler, M. Metzger, L. Just, T. Skutella, et al. Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1 Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1114 - G1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Lane, B. Dvorak, N. K. MacLennan, K. Dvorakova, M. D. Halpern, T. D. Pham, and A. F. Philipps IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1450 - R1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Burrin, B. Stoll, M. Z. Fan, M. A. Dudley, S. M. Donovan, and P. J. Reeds Oral IGF-I Alters the Posttranslational Processing but Not the Activity of Lactase-Phlorizin Hydrolase in Formula-Fed Neonatal Pigs J. Nutr., September 1, 2001; 131(9): 2235 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Chang, J. M. Uribe, S. J. Keely, S. Calandrella, and K. E. Barrett Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G129 - G137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Alexander and H. V. Carey Involvement of PI 3-kinase in IGF-I stimulation of jejunal Na+-K+-ATPase activity and nutrient absorption Am J Physiol Gastrointest Liver Physiol, February 1, 2001; 280(2): G222 - G228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Gillingham, E. M. Dahly, H. V. Carey, M. D. Clark, K. R. Kritsch, and D. M. Ney Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats Am J Physiol Gastrointest Liver Physiol, May 1, 2000; 278(5): G700 - G709. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
