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Am J Physiol Gastrointest Liver Physiol 277: G917-G921, 1999;
0193-1857/99 $5.00
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Vol. 277, Issue 5, G917-G921, November 1999

THEMES
Lessons From Genetically Engineered Animal Models
V. Knocking out genes to study liver regeneration: present and future*

Nelson Fausto

Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195-7470

Studies utilizing knockout mice have contributed important new knowledge about the mechanisms that initiate liver regeneration. New mouse lines need to be established to address major questions about these mechanisms, targeting genes for which there is experimental evidence of their involvement in important pathways. Development of conditional, liver-specific knockout mice would be of great value for these studies.

hepatocytes; cytokines; growth factors; transcription factors

* Fifth in a series of invited articles on Lessons From Genetically Engineered Animal Models.




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