AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 278: G185-G190, 2000;
0193-1857/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shull, G. E.
Right arrow Articles by Schultheis, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shull, G. E.
Right arrow Articles by Schultheis, P. J.
Vol. 278, Issue 2, G185-G190, February 2000

THEMES
Lessons from Genetically Engineered Animal Models
VIII. Absorption and secretion of ions in the gastrointestinal tract*

Gary E. Shull1, Marian L. Miller2, and Patrick J. Schultheis3

1 Department of Molecular Genetics, Biochemistry, and Microbiology and 2 Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267; and 3 Department of Biological Sciences, Northern Kentucky University, Highland Heights, Kentucky 41099

Absorption and secretion of ions in gastrointestinal and other epithelial tissues require the concerted activities of ion pumps, channels, symporters, and exchangers, which operate in coupled systems to mediate transepithelial transport. Our understanding of the identities, membrane locations, and biochemical activities of epithelial ion transporters has advanced significantly in recent years, but major gaps and uncertainties remain in our understanding of their physiological functions. Increasingly, this problem is being addressed by the analysis of mutant mouse models developed by gene targeting. In this review, we discuss gene knockout studies of the secretory isoform of the Na+-K+-2Cl- cotransporter, isoforms 1, 2, and 3 of the Na+/H+ exchanger, and the colonic H+-K+-ATPase. This approach is leading to a clearer understanding of the functions of these transporters in the living animal.

embryonic stem cells; acid secretion; chloride secretion; sodium absorption; potassium absorption

* Eighth in a series of invited articles on Lessons From Genetically Engineered Animal Models.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
N. B. Pestov, T. V. Korneenko, M. I. Shakhparonov, G. E. Shull, and N. N. Modyanov
Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo
Am J Physiol Cell Physiol, August 1, 2006; 291(2): C366 - C374.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. W. Good, T. George, and B. A. Watts III
Nongenomic regulation by aldosterone of the epithelial NHE3 Na+/H+ exchanger
Am J Physiol Cell Physiol, March 1, 2006; 290(3): C757 - C763.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor
Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases
Physiol Rev, April 1, 2005; 85(2): 679 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. W. Good, B. A. Watts III, T. George, J. W. Meyer, and G. E. Shull
Transepithelial HCO3- absorption is defective in renal thick ascending limbs from Na+/H+ exchanger NHE1 null mutant mice
Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1244 - F1249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. Xu, W. Zhang, and B. C. Kone
CREB trans-activates the murine H+-K+-ATPase {alpha}2-subunit gene
Am J Physiol Cell Physiol, October 1, 2004; 287(4): C903 - C911.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. Hecht, K. Hodges, R. K. Gill, F. Kear, S. Tyagi, J. Malakooti, K. Ramaswamy, and P. K. Dudeja
Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells
Am J Physiol Gastrointest Liver Physiol, August 1, 2004; 287(2): G370 - G378.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
W. Zhang, T. Kuncewicz, S. C. Higham, and B. C. Kone
Structure, Promoter Analysis, and Chromosomal Localization of the Murine H+/K+-ATPase {alpha}2 Subunit Gene
J. Am. Soc. Nephrol., December 1, 2001; 12(12): 2554 - 2564.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. MENETON
Comparative Roles of the Renal Apical Sodium Transport Systems in Blood Pressure Control
J. Am. Soc. Nephrol., November 1, 2000; 11(90002): 135S - 139.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. L. Woo, P. F. James, and J. B Lingrel
Sperm Motility Is Dependent on a Unique Isoform of the Na,K-ATPase
J. Biol. Chem., June 30, 2000; 275(27): 20693 - 20699.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online