AJP - GI Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 278: G191-G196, 2000;
0193-1857/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shanahan, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shanahan, F.
Vol. 278, Issue 2, G191-G196, February 2000

THEMES
Nutrient Tasting and Signaling Mechanisms in the Gut
V. Mechanisms of immunologic sensation of intestinal contents*

Fergus Shanahan

Department of Medicine, National University of Ireland, University College Cork and Cork University Hospital, Ireland

Immune perception of intestinal contents reflects a functional dualism with systemic hyporesponsiveness to dietary antigens and resident microflora (oral tolerance) and active immune responses to mucosal pathogens. This facilitates optimal absorption of dietary nutrients while conserving immunologic resources for episodic pathogenic challenge. Discrimination between dangerous and harmless antigens within the enteric lumen requires continual sampling of the microenvironment by multiple potential pathways, innate and adaptive recognition mechanisms, bidirectional lymphoepithelial signaling, and rigorous control of effector responses. Errors in these processes disrupt mucosal homeostasis and are associated with food hypersensitivity and mucosal inflammation. Mechanisms of mucosal immune perception and handling of dietary proteins and other antigens have several practical and theoretical implications including vaccine design, therapy of systemic autoimmunity, and alteration of enteric flora with probiotics.

microflora; dietary antigens; oral tolerance; mucosal immunity; inflammatory bowel diseases; probiotics

* Fifth in a series of invited articles on Nutrient Tasting and Signaling Mechanisms in the Gut.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. O'Mahony, L. O'Callaghan, J. McCarthy, D. Shilling, P. Scully, S. Sibartie, E. Kavanagh, W. O. Kirwan, H. P. Redmond, J. K. Collins, et al.
Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans
Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G839 - G845.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Poult. Res.Home page
L. Revolledo, A. J. P. Ferreira, and G. C. Mead
Prospects in Salmonella Control: Competitive Exclusion, Probiotics, and Enhancement of Avian Intestinal Immunity
J. Appl. Poult. Res., January 1, 2006; 15(2): 341 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
F. Shanahan
Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease
Am J Physiol Gastrointest Liver Physiol, March 1, 2005; 288(3): G417 - G421.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
F Shanahan
Probiotics in inflamatory bowel disease
Gut, May 1, 2001; 48(5): 609 - 609.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online