| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Gastrointestinal Diseases Research Unit, Departments of Medicine, Physiology, and Biology, Queen's University, Kingston, Ontario, Canada K7L 5G2
This study examined synaptic inputs from myenteric neurons innervating submucosal neurons. Intracellular recordings were obtained from submucosal S neurons in guinea pig ileal preparations in vitro, and synaptic inputs were recorded in response to electrical stimulation of exposed myenteric plexus. Most S neurons received synaptic inputs [>80% fast (f) excitatory postsynaptic potentials (EPSP), >30% slow (s) EPSPs] from the myenteric plexus. Synaptic potentials were recorded significant distances aboral (fEPSPs, 25 mm; sEPSPs, 10 mm) but not oral to the stimulating site. When preparations were studied in a double-chamber bath that chemically isolated the stimulating "myenteric chamber" from the recording side "submucosal chamber," all fEPSPs were blocked by hexamethonium in the submucosal chamber, but not by a combination of nicotinic, purinergic, and 5-hydroxytryptamine-3 receptor antagonists in the myenteric chamber. In 15% of cells, a stimulus train elicited prolonged bursts of fEPSPs (>30 s duration) that were blocked by hexamethonium. These findings suggest that most submucosal S neurons receive synaptic inputs from predominantly anally projecting myenteric neurons. These inputs are poised to coordinate intestinal motility and secretion.
intracellular recording; myenteric plexus; submucosal plexus; projections; communication
This article has been cited by other articles:
|
|
 |
|
  M. H. Larsson, M. Sapnara, E. A. Thomas, J. C. Bornstein, E. Lindstrom, D. J. Svensson, and H. Sjovall Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G165 - G173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Reed and S. Vanner Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G608 - G614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Patton, M. O'Reilly, and S. Vanner Sensory peptide neurotransmitters mediating mucosal and distension evoked neural vasodilator reflexes in guinea pig ileum Am J Physiol Gastrointest Liver Physiol, November 1, 2005; 289(5): G785 - G790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Obaid, M. E. Nelson, J. Lindstrom, and B. M. Salzberg Optical studies of nicotinic acetylcholine receptor subtypes in the guinea-pig enteric nervous system J. Exp. Biol., August 1, 2005; 208(15): 2981 - 3001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Chambers, J. C. Bornstein, H. Sjovall, and E. A. Thomas Recurrent networks of submucous neurons controlling intestinal secretion: a modeling study Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G887 - G896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Monro, P. P. Bertrand, and J. C. Bornstein ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum J. Physiol., April 15, 2004; 556(2): 571 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vanner Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum Am J Physiol Gastrointest Liver Physiol, August 1, 2000; 279(2): G380 - G387. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
