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Am J Physiol Gastrointest Liver Physiol 278: G343-G348, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 3, G343-G348, March 2000

THEMES
Lessons From Genetically Engineered Animal Models
IX. Mast cell-deficient mice and intestinal biology*

Barry K. Wershil

Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203

Mutant mice that express abnormalities in mast cell development represent a powerful tool for the investigation of multiple aspects of mast cell biology. In addition, the identification of the genes affected by these mutations has not only increased our knowledge about the mast cell but has opened new areas of investigation as to the role of these gene products in gastrointestinal pathology, immunology, and physiology.

mast cells; stem cell factor; c-kit; neutrophils; neuropeptides

* Ninth in a series of invited articles on Lessons From Genetically Engineered Animal Models.




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