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Am J Physiol Gastrointest Liver Physiol 278: G349-G353, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 3, G349-G353, March 2000

THEMES
Pathobiology of Visceral Pain: Molecular Mechanisms and Theraputic Implications
I. Cellular and molecular biology of sodium channel beta -subunits: therapeutic implications for pain?*

Lori L. Isom

Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109-0632

Voltage-gated sodium channel alpha -subunits have been shown to be key mediators of the pathophysiology of pain. The present review considers the role of sodium channel auxiliary beta -subunits in channel modulation, channel protein expression levels, and interactions with extracellular matrix and cytoskeletal signaling molecules. Although beta -subunits have not yet been directly implicated in pain mechanisms, their intimate association with and ability to regulate alpha -subunits predicts that they may be a viable target for therapeutic intervention in the future. It is proposed that multifunctional sodium channel beta -subunits provide a critical link between extracellular and intracellular signaling molecules and thus have the ability to fine tune channel activity and electrical excitability.

cell adhesion molecules; extracellular matrix

*  First in a series of invited articles on Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications.




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