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Am J Physiol Gastrointest Liver Physiol 278: G354-G366, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 3, G354-G366, March 2000

INVITED REVIEW
Fas and Fas ligand in gut and liver

Michael J. Pinkoski1, Thomas Brunner2, Douglas R. Green1, and Tesu Lin1

1 Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121; and 2 Division of Immunopathology, Institute of Pathology, University of Berne, 3010 Berne, Switzerland

Apoptosis (programmed cell death) has been shown to play a major role in development and in the pathogenesis of numerous diseases. A principal mechanism of apoptosis is molecular interaction between surface molecules known as the "death receptors" and their ligands. Perhaps the best-studied death receptor and ligand system is the Fas/Fas ligand (FasL) system, in which FasL, a member of the tumor necrosis factor (TNF) family of death-inducing ligands, signals death through the death receptor Fas, thereby resulting in the apoptotic death of the cell. Numerous cells in the liver and gastrointestinal tract have been shown to express Fas/FasL, and there is a growing body of evidence that the Fas/FasL system plays a major role in the pathogenesis of many liver and gastrointestinal diseases, such as inflammatory bowel disease, graft vs. host disease, and hepatitis. Here we review the Fas/FasL system and the evidence that it is involved in the pathogenesis of liver and gastrointestinal diseases.

apoptosis; intestine; colitis; hepatitis; transplant


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