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Am J Physiol Gastrointest Liver Physiol 278: G557-G562, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 4, G557-G562, April 2000

Role of GRPergic neurons in secretin-evoked exocrine secretion in isolated rat pancreas

Hyung Seo Park1, Hyeok Yil Kwon1, Yun Lyul Lee1, William Y. Chey2, and Hyoung Jin Park1

1 Department of Physiology, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, Republic of Korea; and 2 Konar Center for Digestive and Liver Diseases, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642

Effects of intrapancreatic gastrin-releasing peptide (GRP)-containing neurons on secretin-induced pancreatic secretion were investigated in the totally isolated perfused rat pancreas. Electrical field stimulation (EFS) increased secretin (12 pM)-induced pancreatic secretions of fluid and amylase. EFS induced a twofold increase in GRP concentration in portal effluent, which was completely inhibited by tetrodotoxin but not modified by atropine. An anti-GRP antiserum inhibited the EFS-enhanced secretin-induced secretions of fluid and amylase by 12 and 43%, respectively, whereas a simultaneous infusion of the antiserum and atropine completely abolished them. Exogenous GRP dose-dependently increased the secretin-induced pancreatic secretion with an additive effect on fluid secretion and a potentiating effect on amylase secretion, which was not affected by atropine. In conclusion, excitation by EFS of GRPergic neurons in the isolated rat pancreas results in the release of GRP, which exerts an additive effect on fluid secretion and a potentiating effect on amylase secretion stimulated by secretin. The release and action of GRP in the rat pancreas are independent of cholinergic tone.

intrapancreatic neuron; immunoneutralization; gastrin-releasing peptide antibody; pancreatic gastrin-releasing peptide release; pancreatic exocrine secretion


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H. S. Park and H. J. Park
Effects of gamma -aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas
Am J Physiol Gastrointest Liver Physiol, October 1, 2000; 279(4): G677 - G682.
[Abstract] [Full Text] [PDF]


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