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Am J Physiol Gastrointest Liver Physiol 278: G665-G669, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 5, G665-G669, May 2000

THEMES
Lessons From Genetically Engineered Animal Models
XI. Novel mouse models to study pathogenic mechanisms of Crohn's disease*

Theresa T. Pizarro, Kristen O. Arseneau, and Fabio Cominelli

Division of Gastroenterology and Hepatology and Digestive Health Research Center, University of Virginia Health System, Charlottesville, Virginia 22906

Crohn's Disease (CD) affects more than 500,000 individuals in the United States and represents the second most common chronic inflammatory disorder after rheumatoid arthritis. Although major advances have been made in defining the basic mechanisms underlying chronic intestinal inflammation, the precise etiopathogenesis of CD remains unknown. We have recently characterized two novel mouse models of enteritis that express a CD-like phenotype, namely the TNF Delta ARE model of tumor necrosis factor (TNF) overexpression and the SAMP1/Yit model of spontaneous ileitis. The unique feature of these models is that they closely resemble CD for location and histopathology. These genetically manipulated new models of intestinal inflammation offer a powerful tool to investigate potential causes of human disease and may allow the development of novel disease-modifying therapeutic modalities for the treatment of CD.

ileitis; cytokines; inflammation

* Eleventh in a series of invited articles on Lessons From Genetically Engineered Animal Models.




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