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Am J Physiol Gastrointest Liver Physiol 278: G670-G676, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 5, G670-G676, May 2000

THEMES
Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications
III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain*

Lionel Buéno, Jean Fioramonti, and Rafael Garcia-Villar

Institut National de la Recherche Agronomique, Neuro-Gastroenterology & Nutrition Unit, 31931 Toulouse, France

Visceral pain is the major cause of consulting in gastroenterology and the principal symptom of functional bowel disorders. This symptom is often associated with gut hypersensitivity to distension. The use of animal models has recently permitted the identification of some mediators supposed to play a pivotal role in the genesis of visceral hypersensitivity. Serotonin, through different receptor subtypes, as well as kinins and calcitonin gene-related peptide, are known to be involved, but other putative transmitters arise and are new potential targets for the development of efficacious treatments. This themes article addresses both physiological and preclinical issues of interest for the selection of active new drugs in regard to the clinical pharmacology of visceral pain.

gut; mediators; hypersensitivity; functional bowel disorders; serotonin; bradykinin; tachykinins; N-methyl-D-aspartate; calcitonin gene-related peptide

* Third in a series of invited articles on Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications.




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