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Am J Physiol Gastrointest Liver Physiol 278: G834-G838, 2000;
0193-1857/00 $5.00
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Vol. 278, Issue 6, G834-G838, June 2000

THEMES
Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications
IV. Visceral afferent contributions to the pathobiology of visceral pain*

G. F. Gebhart

Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, Iowa 52242

Functional bowel and other visceral disorders exhibit multiple characteristics that suggest the presence of visceral hyperalgesia. The discomfort, pain, and altered sensations (e.g., to intraluminal contents) that define the hyperalgesia typically arise in the absence of tissue insult or inflammation. Visceral hyperalgesia thus differs from somatic hyperalgesia, which is commonly associated with tissue injury and inflammation. Hyperalgesia could develop and be maintained by either peripheral or central mechanisms; the altered sensations associated with functional visceral disorders are contributed to by both peripheral and central mechanisms. The relative contributions of peripheral and central mechanisms are not well understood, and the focus in this Themes article is on potential peripheral contributions: sensitization of visceral receptors, nerve injury, and ion channels.

ion channels; mechanosensitive; polymodal; visceral hyperalgesia

* Fourth in a series of invited articles on Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications.




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