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Vol. 279, Issue 1, G148-G156, July 2000

Pancreatic CCK_B receptors: their potential roles in somatostatin release and -cell proliferation

Jean Morisset¹, Helen Wong², John H. Walsh^,2, J. Lainé¹, and Judith Bourassa¹

¹ Service de Gastro-entérologie, Département de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4; and ² CURE Digestive Diseases Research Center, UCLA Medical Center, Los Angeles, California 90073-1792

In rodents, cholecystokinin (CCK) induces pancreatic enzyme secretion and pancreas growth through its CCK_A receptors. It is unknown whether occupation of the CCK_B receptors present in pig and human pancreas can cause the same effects. This study evaluates CCK_B receptor expression in rat, mouse, pig, and fetal human pancreata using Northern blot, Western blot, and immunofluorescence techniques. The reported 2.7-kb CCK_B receptor mRNA transcript in the rat brain and gastric fundus is absent in pancreas; the message was, however, detected by RT-PCR and by a CCK_B receptor antibody as an 80-kDa protein present uniquely in islet -cells. Proteins of 50 and 80 kDa appear in mouse pancreas, and proteins of 50 and 115 kDa appear in pig and human pancreas, respectively, all localized in islet -cells. Gastrin mRNAs are strongly present in fetal rat pancreas, and the hormone is localized in islets; both are repressed 10 days after birth. In conclusion, the CCK_B receptors are present in pancreas of four species with exclusive location in islet -cells. In such a location, they could be indirectly involved in the control of enzyme secretion.

rat; mouse; pig; human; cholecystokinin

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 Deceased 14 June 2000.

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