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Am J Physiol Gastrointest Liver Physiol 279: G148-G156, 2000;
0193-1857/00 $5.00
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Vol. 279, Issue 1, G148-G156, July 2000

Pancreatic CCKB receptors: their potential roles in somatostatin release and delta -cell proliferation

Jean Morisset1, Helen Wong2, John H. Walshdagger,2, J. Lainé1, and Judith Bourassa1

1 Service de Gastro-entérologie, Département de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4; and 2 CURE Digestive Diseases Research Center, UCLA Medical Center, Los Angeles, California 90073-1792

In rodents, cholecystokinin (CCK) induces pancreatic enzyme secretion and pancreas growth through its CCKA receptors. It is unknown whether occupation of the CCKB receptors present in pig and human pancreas can cause the same effects. This study evaluates CCKB receptor expression in rat, mouse, pig, and fetal human pancreata using Northern blot, Western blot, and immunofluorescence techniques. The reported 2.7-kb CCKB receptor mRNA transcript in the rat brain and gastric fundus is absent in pancreas; the message was, however, detected by RT-PCR and by a CCKB receptor antibody as an 80-kDa protein present uniquely in islet delta -cells. Proteins of 50 and 80 kDa appear in mouse pancreas, and proteins of 50 and 115 kDa appear in pig and human pancreas, respectively, all localized in islet delta -cells. Gastrin mRNAs are strongly present in fetal rat pancreas, and the hormone is localized in islets; both are repressed 10 days after birth. In conclusion, the CCKB receptors are present in pancreas of four species with exclusive location in islet delta -cells. In such a location, they could be indirectly involved in the control of enzyme secretion.

rat; mouse; pig; human; cholecystokinin

dagger  Deceased 14 June 2000.




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