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Am J Physiol Gastrointest Liver Physiol 279: G211-G222, 2000;
0193-1857/00 $5.00
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Vol. 279, Issue 1, G211-G222, July 2000

The endothelin system in normal human colon

Giorgia Egidy1, Lucienne Juillerat-Jeanneret2, Petra Korth1, Fred T. Bosman2, and Florence Pinet1

1 Institut National de la Santé et de la Recherche Médicale Unit 36, Collège de France, 75005 Paris, France; and 2 Institute of Pathology, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland

Endothelin (ET)-1 is a potent vasoconstrictor and mitogenic peptide that has a variety of biological effects in noncardiovascular tissues. The precise cellular distribution of the ET-1 system in the wall of the normal human colon was studied to identify the physiological role of ET in the gut. In situ hybridization revealed ET-converting enzyme-1 (ECE-1) mRNA in all vessels, the colon epithelium, and macrophages. Prepro-ET-1 (PPET-1) mRNA had a similar distribution except for a scattered signal in mucosal microvessels. ETA and ETB receptor mRNAs were mainly in the lamina propria, pericryptal myofibroblasts, microvessels, and mononuclear cells, with ETA mRNA more abundant than ETB mRNA. 125I-ET-1 binding showed ETB along the crypts and in nerve fibers descending from the ganglionic plexus that contained PPET-1, ECE-1, and ETB transcripts, whereas glia contained ETA receptors. The finding of the entire ET system in the normal mucosa suggests its implication in some characteristic functions of the colon and its secretion as both a neuroactive and a vasoactive peptide.

in situ hybridization; immunocytochemistry; endothelial cell; smooth muscle cell


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