| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
The ability of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors to exacerbate inflammatory bowel disease suggests that prostaglandins are important anti-inflammatory mediators in this context. Prostaglandin D2 has been suggested to exert anti-inflammatory effects. We investigated the possibility that prostaglandin D2 derived from cyclooxygenase-2 plays an important role in downregulating colonic inflammation in rats. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid. At various times thereafter (from 1 h to 7 days), colonic prostaglandin synthesis and myeloperoxidase activity (index of granulocyte infiltration) were measured. Prostaglandin D2 synthesis was elevated >4-fold above controls within 1-3 h of induction of colitis, preceding significant granulocyte infiltration. Treatment with a selective cyclooxygenase-2 inhibitor abolished the increase in prostaglandin D2 synthesis and caused a doubling of granulocyte infiltration. Colonic granulocyte infiltration was significantly reduced by administration of prostaglandin D2 or a DP receptor agonist (BW-245C). These results demonstrate that induction of colitis results in a rapid increase in prostaglandin D2 synthesis via cyclooxygenase-2. Prostaglandin D2 downregulates granulocyte infiltration into the colonic mucosa, probably through the DP receptor.
inflammation; inflammatory bowel disease; neutrophil; DP receptor
This article has been cited by other articles:
|
|
 |
|
  S. Hyo, R. Kawata, K. Kadoyama, N. Eguchi, T. Kubota, H. Takenaka, and Y. Urade Expression of Prostaglandin D2 Synthase in Activated Eosinophils in Nasal Polyps Arch Otolaryngol Head Neck Surg, July 1, 2007; 133(7): 693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rajakariar, M. M. Yaqoob, and D. W. Gilroy COX-2 in Inflammation and Resolution Mol. Interv., August 1, 2006; 6(4): 199 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Hatoum, K. M. Gauthier, D. G. Binion, H. Miura, G. Telford, M. F. Otterson, W. B. Campbell, and D. D. Gutterman Novel Mechanism of Vasodilation in Inflammatory Bowel Disease Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2355 - 2361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Shifflett, S. L. Jones, A. J. Moeser, and A. T. Blikslager Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G906 - G913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gosset, F. Bureau, V. Angeli, M. Pichavant, C. Faveeuw, A.-B. Tonnel, and F. Trottein Prostaglandin D2 Affects the Maturation of Human Monocyte-Derived Dendritic Cells: Consequence on the Polarization of Naive Th Cells J. Immunol., May 15, 2003; 170(10): 4943 - 4952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Monneret, H. Li, J. Vasilescu, J. Rokach, and W. S. Powell 15-Deoxy-{Delta}12,1412,14-prostaglandins D2 and J2 Are Potent Activators of Human Eosinophils J. Immunol., April 1, 2002; 168(7): 3563 - 3569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirai, K. Tanaka, S. Takano, M. Ichimasa, M. Nakamura, and K. Nagata Cutting Edge: Agonistic Effect of Indomethacin on a Prostaglandin D2 Receptor, CRTH2 J. Immunol., February 1, 2002; 168(3): 981 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Mifflin, J. I. Saada, J. F. Di Mari, P. A. Adegboyega, J. D. Valentich, and D. W. Powell Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction Am J Physiol Cell Physiol, April 1, 2002; 282(4): C824 - C834. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
