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Am J Physiol Gastrointest Liver Physiol 279: G7-G11, 2000;
0193-1857/00 $5.00
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Vol. 279, Issue 1, G7-G11, July 2000

THEME
Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex

Francis J. Eng and Scott L. Friedman

Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029

Hepatic stellate cell activation is a complex process. Paradoxes and controversies include the origin(s) of hepatic stellate cells, the regulation of membrane receptor signaling and transcription, and the fate of the cells once liver injury resolves. Major themes have emerged, including the dominance of autocrine signaling and the identification of counterregulatory stimuli that oppose key features of activated cells. Advances in analytical methods including proteomics and gene array, coupled with powerful bioinformatics, promise to revolutionize how we view cellular responses. Our understanding of stellate cell activation is likely to benefit from these advances, unearthing modes of regulating cellular behavior that are not even conceivable on the basis of current paradigms.

signaling; transcription; extracellular matrix; receptors; hepatic fibrosis


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