AJP - GI Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 279: G388-G399, 2000;
0193-1857/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dickens, E. J.
Right arrow Articles by Hirst, G. D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dickens, E. J.
Right arrow Articles by Hirst, G. D. S.
Vol. 279, Issue 2, G388-G399, August 2000

Vagal inhibition in the antral region of guinea pig stomach

Emma J. Dickens, F. R. Edwards, and G. D. S. Hirst

Department of Zoology, University of Melbourne, Parkville, Victoria 3052, Australia

The effects of vagal stimulation in the presence of a muscarinic antagonist were examined on three distinct rhythmically active cells located in guinea pig antrum. Vagal stimulation inhibited contractions of the circular muscle layer but did not change their rate of occurrence. With the use of intracellular recording techniques, these stimuli were found to initiate inhibitory junction potentials in the circular layer but produced smaller potential changes in driving and follower cells. Inhibition of the circular muscle layer involved two separate components. The dominant component was independent of changes in membrane potential and was abolished by nitro-L-arginine. After abolishing Ca2+ entry into smooth muscle cells with a Ca2+ antagonist, vagal stimulation continued to inhibit the residual contractions associated with each slow wave. When the cyclic changes in intracellular Ca2+ concentration associated with each slow wave were measured, they were found to be unchanged by vagal stimulation. The observations suggest that vagal inhibition of stomach movements does not alter pacemaker activity in the stomach; rather, it results from a change in the sensitivity of smooth muscle contractile proteins to Ca2+.

smooth muscle; slow waves; driving cells; inhibition


This article has been cited by other articles:


Home page
 J. Physiol.Home page
Y. Takeda, S. D. Koh, K. M. Sanders, and S. M. Ward
Differential expression of ionic conductances in interstitial cells of Cajal in the murine gastric antrum
J. Physiol., February 1, 2008; 586(3): 859 - 873.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Hashitani and H. Suzuki
Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ
J. Physiol., September 1, 2007; 583(2): 505 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. M. Sanders and S. M. Ward
Kit mutants and gastrointestinal physiology
J. Physiol., January 1, 2007; 578(1): 33 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Yun Cho, E. A. Beckett, S. A. Baker, I. Han, K. J. Park, K. Monaghan, S. M. Ward, K. M. Sanders, and S. D. Koh
A pH-sensitive potassium conductance (TASK) and its function in the murine gastrointestinal tract
J. Physiol., May 15, 2005; 565(1): 243 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. E. Daniel
Physiology and Pathophysiology of the Interstitial Cell of Cajal: From Bench to Bedside: III. Interaction of interstitial cells of Cajal with neuromediators: an interim assessment
Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1329 - G1332.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online