AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 279: G477-G482, 2000;
0193-1857/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (101)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cereijido, M.
Right arrow Articles by Contreras, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cereijido, M.
Right arrow Articles by Contreras, R. G.
Vol. 279, Issue 3, G477-G482, September 2000

THEME

Molecular Physiology and Pathophysiology of Tight Junctions I. Biogenesis of tight junctions and epithelial polarity

M. Cereijido, L. Shoshani, and R. G. Contreras

Center for Research and Advanced Studies, 07000 Mexico City, Mexico

The tight junction (TJ) was first noticed through its ability to control permeation across the paracellular route, but the homologies of its molecular components with peptides that participate in tumor suppression, nuclear addressing, and cell proliferation indicate that it may be involved in many other fundamental functions. TJs are formed by a dozen molecular species that assemble through PDZ and other protein-protein clustering promoting sequences, in response to the activation of E-cadherin. The TJ occupies a highly specific position between the apical and the basolateral domains. Its first molecular components seem to be delivered to such a position by addressing signals in their molecule and, once anchored, serve as a clustering nucleus for further TJ-associated molecules. Although in mature epithelial cells TJs and E-cadherin do not colocalize, a complex chain of reactions goes from one to the other that involves alpha -, beta -, and gamma -catenins, two different G proteins, phospholipase C, protein kinase C, calmodulin, mitogen-activated protein kinase, and molecules pertaining to the cytoskeleton, which keep the TJ sensitive to physiological requirements and local conditions (notably to Ca2+-dependent cell-cell contacts) throughout the life of the epithelium.

apical membrane; basolateral membrane; polarity; E-cadherin; zonula occludens-1; occludin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
A. B. Singh, K. Sugimoto, P. Dhawan, and R. C. Harris
Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1660 - C1668.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. E. Ridyard, J. K. Brown, S. M. Rhind, R. W. Else, J. W. Simpson, and H. R.P. Miller
Apical Junction Complex Protein Expression in the Canine Colon: Differential Expression of Claudin-2 in the Colonic Mucosa in Dogs With Idiopathic Colitis
J. Histochem. Cytochem., October 1, 2007; 55(10): 1049 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. T. Blikslager, A. J. Moeser, J. L. Gookin, S. L. Jones, and J. Odle
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiol Rev, April 1, 2007; 87(2): 545 - 564.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Boireau, M. Buchert, M. S. Samuel, J. Pannequin, J. L. Ryan, A. Choquet, H. Chapuis, X. Rebillard, C. Avances, M. Ernst, et al.
DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma
Carcinogenesis, February 1, 2007; 28(2): 246 - 258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Flores-Benitez, A. Ruiz-Cabrera, C. Flores-Maldonado, L. Shoshani, M. Cereijido, and R. G. Contreras
Control of tight junctional sealing: role of epidermal growth factor
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F828 - F836.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. T. Chartier, M. Laine, S. Gout, G. Pawlak, C. A. Marie, P. Matos, M. R. Block, and M. R. Jacquier-Sarlin
Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells
J. Cell Sci., January 1, 2006; 119(1): 31 - 46.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
G A Gill, A Buda, M Moorghen, P W Dettmar, and M Pignatelli
Characterisation of adherens and tight junctional molecules in normal animal larynx; determining a suitable model for studying molecular abnormalities in human laryngopharyngeal reflux
J. Clin. Pathol., December 1, 2005; 58(12): 1265 - 1270.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Matsuzawa, A. Kuwae, and A. Abe
Enteropathogenic Escherichia coli Type III Effectors EspG and EspG2 Alter Epithelial Paracellular Permeability
Infect. Immun., October 1, 2005; 73(10): 6283 - 6289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
X. Guo, J. N. Rao, L. Liu, T. Zou, K. M. Keledjian, D. Boneva, B. S. Marasa, and J.-Y. Wang
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells
Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1159 - G1169.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Cereijido, R. G. Contreras, and L. Shoshani
Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans
Physiol Rev, October 1, 2004; 84(4): 1229 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. A. Tobey, C. M. Argote, S. S. Hosseini, and R. C. Orlando
Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium
Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G1042 - G1049.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Neunlist, F. Toumi, T. Oreschkova, M. Denis, J. Leborgne, C. L. Laboisse, J.-P. Galmiche, and A. Jarry
Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways
Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G1028 - G1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. Guo, J. N. Rao, L. Liu, T.-T. Zou, D. J. Turner, B. L. Bass, and J.-Y. Wang
Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines
Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1174 - C1187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. K. Rajasekaran and S. A. Rajasekaran
Role of Na-K-ATPase in the assembly of tight junctions
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F388 - F396.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M.-H. Wang, D. Wang, and Y.-Q. Chen
Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase
Carcinogenesis, August 1, 2003; 24(8): 1291 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
G. Benais-Pont, A. Punn, C. Flores-Maldonado, J. Eckert, G. Raposo, T. P. Fleming, M. Cereijido, M. S. Balda, and K. Matter
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability
J. Cell Biol., March 3, 2003; 160(5): 729 - 740.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. S. Balda, M. D. Garrett, and K. Matter
The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
J. Cell Biol., February 3, 2003; 160(3): 423 - 432.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Grande, A. Franzen, J.-O. Karlsson, L. E. Ericson, N.-E. Heldin, and M. Nilsson
Transforming growth factor-{beta} and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes
J. Cell Sci., November 15, 2002; 115(22): 4227 - 4236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. C. Chen, T. E. Solomon, R. Kui, and A. H. Soll
Apical EGF receptors regulate epithelial barrier to gastric acid: endogenous TGF-alpha is an essential facilitator
Am J Physiol Gastrointest Liver Physiol, November 1, 2002; 283(5): G1098 - G1106.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. Y. Cheng and D. D. Mruk
Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development
Physiol Rev, October 1, 2002; 82(4): 825 - 874.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
V. Nunbhakdi-Craig, T. Machleidt, E. Ogris, D. Bellotto, C. L. White III, and E. Sontag
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
J. Cell Biol., September 3, 2002; 158(5): 967 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
F. Kassab Jr., R. P. Marques, and F. Lacaz-Vieira
Modeling Tight Junction Dynamics and Oscillations
J. Gen. Physiol., July 30, 2002; 120(2): 237 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Schreider, G. Peignon, S. Thenet, J. Chambaz, and M. Pincon-Raymond
Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes
J. Cell Sci., January 2, 2002; 115(3): 543 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Kunzelmann and M. Mall
Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease
Physiol Rev, January 1, 2002; 82(1): 245 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Niimi, K. Nagashima, J. M. Ward, P. Minoo, D. B. Zimonjic, N. C. Popescu, and S. Kimura
claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing
Mol. Cell. Biol., November 1, 2001; 21(21): 7380 - 7390.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. J. Cavanaugh Jr., J. Oswari, and S. S. Margulies
Role of Stretch on Tight Junction Structure in Alveolar Epithelial Cells
Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 584 - 591.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. B. Serikov, Y. J. Jang, and J. H. Widdicombe
Estimate of the subepithelial hydrostatic pressure that drives inflammatory transudate into the airway lumen
J Appl Physiol, April 1, 2002; 92(4): 1702 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Notterpek, K. J. Roux, S. A. Amici, A. Yazdanpour, C. Rahner, and B. S. Fletcher
Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia
PNAS, December 4, 2001; 98(25): 14404 - 14409.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online