AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 279: G700-G706, 2000;
0193-1857/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ljungmann, K.
Right arrow Articles by Laurberg, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ljungmann, K.
Right arrow Articles by Laurberg, S.
Vol. 279, Issue 4, G700-G706, October 2000

GH decreases hepatic amino acid degradation after small bowel resection in rats without enhancing bowel adaptation

K. Ljungmann1,2, T. Grøfte3, P. Kissmeyer-Nielsen1, A. Flyvbjerg4, H. Vilstrup3, N. Tygstrup5, and S. Laurberg1

1 Surgical Research Unit, Department of Surgery L, 2 Stereological Research Laboratory, 3 Department of Medicine V, and 4 Medical Research Laboratory M (Diabetes and Endocrinology), University Hospital of Aarhus, DK-8000 Aarhus C; and 5 Department of Medicine A, State University Hospital, 2100 Copenhagen, Denmark

Growth hormone (GH) treatment in short bowel syndrome is controversial, and the mechanisms of a possible positive effect remain to be elucidated. Rats were randomly subjected to either an 80% jejunoileal resection or sham operation and were given either placebo (NaCl) or biosynthetic rat GH (brGH). The in vivo capacity of urea nitrogen synthesis (CUNS) and the expression of urea cycle enzymes were measured and related to changes in body weight and adaptive growth in ileal segments on days 7 and 14. Ileal segments were examined by unbiased stereological techniques. brGH treatment decreased CUNS among the resected rats by 19% (P < 0.05) and 36% (P < 0.05) on days 7 and 14, respectively. The mRNA levels of urea cycle enzyme genes were not influenced by brGH treatment. brGH treatment did not increase the adaptive growth in the ileal segments. In conclusion, we found that GH treatment decreased the accelerated postoperative hepatic amino acid degradation in experimental short bowel syndrome without enhancing the morphological intestinal adaptation.

insulin-like growth factor-I; urea metabolism; mRNA levels; short bowel syndrome; stereology


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Ljungmann, B. Hartmann, P. Kissmeyer-Nielsen, A. Flyvbjerg, J. J. Holst, and S. Laurberg
Time-dependent intestinal adaptation and GLP-2 alterations after small bowel resection in rats
Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G779 - G785.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online