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Am J Physiol Gastrointest Liver Physiol 279: G845-G850, 2000;
0193-1857/00 $5.00
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Vol. 279, Issue 5, G845-G850, November 2000

THEME
Fibrogenesis
V. TGF-beta signaling pathways

Rebecca G. Wells

Departments of Internal Medicine and Pathology, Yale School of Medicine, New Haven, Connecticut 06520-8019

Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.

fibrosis; extracellular matrix; transforming growth factor-beta receptors; Smads


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