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Am J Physiol Gastrointest Liver Physiol 279: G998-G1002, 2000;
0193-1857/00 $5.00
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Vol. 279, Issue 5, G998-G1002, November 2000

Expression of cell volume-regulated kinase h-sgk in pancreatic tissue

K. Klingel1, S. Wärntges2, J. Bock2, C. A. Wagner2, M. Sauter1, S. Waldegger2, R. Kandolf1, and F. Lang2

1 Department of Molecular Pathology, Institute of Pathology and 2 Institute of Physiology, University of Tübingen, D-72076, Tübingen, Germany

Transcript levels of the human serine/threonine kinase h-sgk have been found to be highest in pancreas. In the present study, localization and regulation of h-sgk transcription in pancreatic tissue were elucidated. As was apparent from radioactive in situ hybridization, most pancreatic acinar cells expressed high levels of h-sgk mRNA. h-sgk mRNA-positive cells were also found in ductal epithelia but not in pancreatic islets. In biopsy specimens from patients with pancreatitis, h-sgk mRNA levels were decreased in acinar cells but abundant in numerous mononuclear interstitial cells within areas of pancreatic necrosis and fibrosis. As shown by Northern blotting, h-sgk transcription in DAN-G pancreatic tumor cells is upregulated by osmotic cell shrinkage, serum, phorbol esters (phorbol 12,13-didecanoate), and Ca2+ ionophore A-23187 and decreased by staurosporine and cAMP. In conclusion, h-sgk transcription is regulated not only by cell volume but also by serum, protein kinase C stimulation, cAMP, and increase of intracellular Ca2+ activity. The kinase may participate not only in normal function of exocrine pancreas but also in fibrosing pancreatitis.

serine/threonine kinase; acinar cells; pancreatitis; pancreatic ducts; macrophages


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