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Am J Physiol Gastrointest Liver Physiol 280: G121-G129, 2001;
0193-1857/01 $5.00
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Vol. 280, Issue 1, G121-G129, January 2001

Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate

Ingrid Synnerstad, Mia Johansson, Olof Nylander, and Lena Holm

Department of Physiology, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden

The acid-secreting gastric mucosa resists intraluminal acid better than the nonsecreting. Here we investigated pH at the epithelial cell surface, mucosal permeability, and blood flow during intraluminal administration of acid (100 mM) in acid-stimulated and nonstimulated gastric corpus mucosae. Surface pH (H+-selective microelectrodes), permeability (clearance of 51Cr-EDTA), and mucosal blood flow (laser-Doppler flowmetry) were studied in Inactin-anesthetized rats. Acid secretion was stimulated with pentagastrin (40 µg · kg-1 · h-1) or impromidine (500 µg · kg-1 · h-1), or HCO3- (5 mmol · kg-1 · h-1) given intravenously. Surface pH was only slightly reduced by intraluminal acid in acid secretion-stimulated or HCO3--treated rats but was substantially lowered in nonstimulated rats. Clearance increased threefold and blood flow increased by approx 75% in nonstimulated rats. During stimulated acid secretion or intravenous infusion of HCO3-, clearance was unchanged and blood flow increased by only approx 30% during intraluminal acid. Increased epithelial transport of HCO3- buffering the mucus gel is most probably the explanation for the acid-secreting mucosa being less vulnerable to intraluminal acid than the nonsecreting.

gastric acid; laser-Doppler flowmetry; permeability; rat


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