| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
The influence of stress on the clinical course of a number of intestinal diseases is increasingly being recognized, but the underlying mechanisms are largely unknown. This themes article focuses on recent findings related to the effects of stress on mucosal barrier function in the small intestine and colon. Experiments using animal models demonstrate that various types of psychological and physical stress induce dysfunction of the intestinal barrier, resulting in enhanced uptake of potentially noxious material (e.g., antigens, toxins, and other proinflammatory molecules) from the gut lumen. Evidence from several studies indicates that in this process, mucosal mast cells play an important role, possibly activated via neurons releasing corticotropin-releasing hormone and/or acetylcholine. Defining the role of specific cells and mediator molecules in stress-induced barrier dysfunction may provide clues to novel treatments for intestinal disorders.
epithelium; permeability; ion secretion; antigen uptake
This article has been cited by other articles:
|
|
 |
|
  A. Wald and D. Rakel Behavioral and Complementary Approaches for the Treatment of Irritable Bowel Syndrome Nutr Clin Pract, June 1, 2008; 23(3): 284 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Johnson-Henry, K. A. Donato, G. Shen-Tu, M. Gordanpour, and P. M. Sherman Lactobacillus rhamnosus Strain GG Prevents Enterohemorrhagic Escherichia coli O157:H7-Induced Changes in Epithelial Barrier Function Infect. Immun., April 1, 2008; 76(4): 1340 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Farre, R. De Vos, K. Geboes, K. Verbecke, P. V. Berghe, I. Depoortere, K. Blondeau, J. Tack, and D. Sifrim Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces Gut, September 1, 2007; 56(9): 1191 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Million, L. Wang, M. P. Stenzel-Poore, S. C. Coste, P. Q. Yuan, C. Lamy, J. Rivier, T. Buffington, and Y. Tache Enhanced pelvic responses to stressors in female CRF-overexpressing mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1429 - R1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Boudry, C. I. Cheeseman, and M. H. Perdue Psychological stress impairs Na+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R862 - R867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Zareie, K Johnson-Henry, J Jury, P-C Yang, B-Y Ngan, D M McKay, J D Soderholm, M H Perdue, and P M Sherman Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress Gut, November 1, 2006; 55(11): 1553 - 1560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kordasti, M. Sapnara, E. A. Thomas, E. Lindstrom, M. Forsman, J. C. Bornstein, and H. Sjovall Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G948 - G958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nazli, A. Wang, O. Steen, D. Prescott, J. Lu, M. H. Perdue, J. D. Soderholm, P. M. Sherman, and D. M. McKay Enterocyte Cytoskeleton Changes Are Crucial for Enhanced Translocation of Nonpathogenic Escherichia coli across Metabolically Stressed Gut Epithelia Infect. Immun., January 1, 2006; 74(1): 192 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Timmerman, L. Mulder, H. Everts, D. C. van Espen, E. van der Wal, G. Klaassen, S. M. G. Rouwers, R. Hartemink, F. M. Rombouts, and A. C. Beynen Health and Growth of Veal Calves Fed Milk Replacers With or Without Probiotics J Dairy Sci, June 1, 2005; 88(6): 2154 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. Sivarao, K. Newberry, S. Langdon, A. V. Lee, P. Hewawasam, M. J. Plym, L. Signor, R. Myers, and N. J. Lodge Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 840 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Bosch, E. J. C. de Geus, E. C. I. Veerman, J. Hoogstraten, and A. V. Nieuw Amerongen Innate Secretory Immunity in Response to Laboratory Stressors That Evoke Distinct Patterns of Cardiac Autonomic Activity Psychosom Med, March 1, 2003; 65(2): 245 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Soderholm, D. A. Yates, M. G. Gareau, P.-C. Yang, G. MacQueen, and M. H. Perdue Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress Am J Physiol Gastrointest Liver Physiol, December 1, 2002; 283(6): G1257 - G1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J D Soderholm, G Olaison, K H Peterson, L E Franzen, T Lindmark, M Wiren, C Tagesson, and R Sjodahl Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease Gut, March 1, 2002; 50(3): 307 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kunzelmann and M. Mall Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease Physiol Rev, January 1, 2002; 82(1): 245 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Yates, J. Santos, J. D. Soderholm, and M. H. Perdue Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G124 - G128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Santos, P-C Yang, J D Soderholm, M Benjamin, and M H Perdue Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat Gut, May 1, 2001; 48(5): 630 - 636. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
