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Departments of 1 Surgery and 2 Anatomy, Shiga University of Medical Science, Otsu, Shiga 520-2192; 3 Pharmaceutical Research Department, Ube Research Laboratory, Ube, Yamaguchi 755-8633; and 4 Second Department of Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, Japan
Since few
previous studies have examined the effects of urocortin on
physiological fed and fasted gastrointestinal motility, we administered
urocortin intracerebroventricularly (icv) or intravenously (iv) in
freely moving conscious rats and examined the changes in antral and
duodenal motility. Icv and iv injection of urocortin disrupted fasted
motor patterns of gastroduodenal motility, which were replaced by
fed-like motor patterns. When urocortin was given icv and iv in the fed
state, the motor activity remained like the fed patterns but % motor
index (%MI) was decreased in the antrum and increased in the duodenum.
Increase in the %MI in the duodenum induced by urocortin was shown as
a nonpropagated event, since the transit of nonnutrient contents in the
duodenum was decreased by icv and iv injection of urocortin. Changes in
the gastroduodenal motility induced by icv injection of urocortin were
abolished in animals with truncal vagotomy but not altered in animals
with mechanical sympathectomy, suggesting that the vagal pathway may
mediate the central action of urocortin. Neither urocortin antiserum
nor 
-helical CRF-(9-41) affected fed and fasted
gastroduodenal motility, suggesting that endogenous urocortin is not
involved in regulation of basal gastroduodenal motility.
intracerebroventricular injection; intravenous injection; stomach; duodenum
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