AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 280: G858-G865, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beno, D. W. A.
Right arrow Articles by Kimura, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beno, D. W. A.
Right arrow Articles by Kimura, R. E.
Vol. 280, Issue 5, G858-G865, May 2001

Endotoxin-induced reduction in biliary indocyanine green excretion rate in a chronically catheterized rat model

David W. A. Beno, Michael R. Uhing, Masakatsu Goto, Yong Chen, Vanida A. Jiyamapa-Serna, and Robert E. Kimura

Section of Neonatology, Department of Pediatrics, Rush Children's Hospital, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612

Using a nonstressed chronically catheterized rat model in which the common bile duct was cannulated, we studied endotoxin-induced alterations in hepatic function by measuring changes in the maximal steady-state biliary excretion rate of the anionic dye indocyanine green (ICG). Biliary excretion of ICG was calculated from direct measurements of biliary ICG concentrations and the bile flow rate during a continuous vascular infusion of ICG. Despite significant elevations in mean peak serum tumor necrosis factor-alpha (TNF-alpha ) concentrations (90.9 ± 16.2 ng/ml), there was no effect on mean rates of bile flow or biliary ICG clearance after administration of 100 µg/kg endotoxin at 6 or 24 h. Significant differences from mean baseline rates of bile flow and biliary ICG excretion did occur after administration of 1,000 µg/kg endotoxin (mean peak TNF-alpha 129.6 ± 24.4 ng/ml). Furthermore, when rats were treated with up to 16 µg/kg of recombinant TNF-alpha , there was no change in mean rates of bile flow or ICG biliary clearance compared with baseline values. These data suggest that the complex regulation of biliary excretion is not mediated solely by TNF-alpha .

tumor necrosis factor-alpha ; hepatocellular dysfunction; sepsis; cholestasis; in vivo studies


This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
S. K. Quinney, R. E. Galinsky, V. A. Jiyamapa-Serna, Y. Chen, M. A. Hamman, S. D. Hall, and R. E. Kimura
Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats
Drug Metab. Dispos., June 1, 2008; 36(6): 1097 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. W. A. Beno, M. R. Uhing, M. Goto, Y. Chen, V. A. Jiyamapa-Serna, and R. E. Kimura
Staphylococcal enterotoxin B potentiates LPS-induced hepatic dysfunction in chronically catheterized rats
Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G866 - G872.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online