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Am J Physiol Gastrointest Liver Physiol 280: G949-G957, 2001;
0193-1857/01 $5.00
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Vol. 280, Issue 5, G949-G957, May 2001

Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon

Carol Bossone1, Jeanette M. Hosseini1, Victor Piñeiro-Carrero2, and Terez Shea-Donohue1,3

Departments of 1 Physiology, 2 Pediatrics, and 3 Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799

In inflammatory bowel disease, smooth muscle function reportedly varies with disease duration. The aim of these studies was to determine changes in the control of spontaneous contractions in a model of experimental colitis that included reinflammation of the healed area. The amplitude and frequency of spontaneous contractions in circular smooth muscle were determined after intrarectal administration of trinitrobenzenesulfonic acid in rat distal colon. With the use of a novel paradigm, rats were studied 4 h (acute) or 28 days (healed) after the initial inflammation. At 28 days, rats were studied 4 h after a second inflammation (reinflamed) of the colon. Colitis induced transient increases in the amplitude of spontaneous contractions coincident with a loss of nitric oxide synthase activity. The frequency of contractions was controlled by constitutive nitric oxide in controls. Frequency was increased in healed and reinflamed colon and was associated with a shift in the dominance of neural constitutive nitric oxide synthase control to that of inducible nitric oxide synthase (iNOS). The initial colitis induced a remodeling of the neural control of spontaneous contractions reflecting changes in their regulation by constitutive nitric oxide synthase and iNOS.

inflammation; colitis; rat; nitric oxide; smooth muscle; enteric nerves


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