AJP - GI Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 280: G1099-G1105, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yu, P.-L.
Right arrow Articles by Fujimiya, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yu, P.-L.
Right arrow Articles by Fujimiya, M.
Vol. 280, Issue 6, G1099-G1105, June 2001

Mechanisms in regulating the release of serotonin from the perfused rat stomach

P.-L. Yu1, M. Fujimura1, N. Hayashi2, T. Nakamura2, and M. Fujimiya2

1 Department of 2nd Surgery and 2 Anatomy, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192, Japan

The mechanisms regulating the release of serotonin into the portal circulation as well as into the gastric lumen were studied in the isolated vascularly and luminally perfused rat stomach. Immunohistochemical study of the rat stomach showed that serotonin-containing enterochromaffin (EC) cells were densely packed in the antral mucosa, sparsely scattered in the corpus, and not found in the fundus. Such morphological findings suggest that serotonin detected in this study may have originated from antral EC cells. Luminal acidification stimulated the vascular release of serotonin but did not affect the luminal release of serotonin. The basal release of serotonin into the vasculature was 10 times higher than that into the gastric lumen at intragastric pH 2. The vascular release of serotonin is regulated by stimulation from cholinergic nicotinic mechanisms, whereas inhibitory neurotransmitters such as vasoactive intestinal peptide and NO are probably not involved. Somatostatin and peptide YY originating from endocrine cells may exert direct inhibitory effects, possibly via somatostatin and peptide YY receptors on the EC cells, and a cholinergic muscarinic mechanism may exert indirect effects on the vascular release of serotonin via the muscarinic receptor on the endocrine cells.

isolated perfusion; enterochromaffin cells; somatostatin; peptide YY


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. H. Mueller, B. Xue, J. Glatzle, J. Hahn, D. Grundy, and M. E. Kreis
Extrinsic afferent nerve sensitivity and enteric neurotransmission in murine jejunum in vitro
Am J Physiol Gastrointest Liver Physiol, October 1, 2009; 297(4): G655 - G662.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. B. Matondo, C. Punt, J. Homberg, M. J. M. Toussaint, R. Kisjes, S. J. A. Korporaal, J. W. N. Akkerman, E. Cuppen, and A. de Bruin
Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration
Am J Physiol Gastrointest Liver Physiol, April 1, 2009; 296(4): G963 - G968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. R. Hayes, F. M. Chory, C. A. Gallagher, and M. Covasa
Serotonin type-3 receptors mediate cholecystokinin-induced satiation through gastric distension
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R115 - R123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Mazda, H. Yamamoto, M. Fujimura, and M. Fujimiya
Gastric distension-induced release of 5-HT stimulates c-fos expression in specific brain nuclei via 5-HT3 receptors in conscious rats
Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G228 - G235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. R. Gower Jr., J. R. Dietz, R. W. McCuen, P. J. Fabri, E. A. Lerner, and M. L. Schubert
Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum
Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G68 - G74.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online