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Am J Physiol Gastrointest Liver Physiol 280: G1227-G1233, 2001;
0193-1857/01 $5.00
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Vol. 280, Issue 6, G1227-G1233, June 2001

Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI

Luca Marciani1, Penny A. Gowland1, Robin C. Spiller2, Pretima Manoj3, Rachel J. Moore1, Paul Young1, and Annette J. Fillery-Travis3

1 Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD; 2 Division of Gastroenterology, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH; and 3 Institute of Food Research, Colney, Norwich NR4 7UA, United Kingdom

The relationship between the intragastric distribution, dilution, and emptying of meals and satiety was studied using noninvasive magnetic resonance imaging techniques in 12 healthy subjects with four polysaccharide test meals of varying viscosity and nutrient content as follows: 1) low-viscosity nonnutrient, 2) low-viscosity nutrient, 3) high-viscosity nonnutrient, and 4) high-viscosity nutrient. Increasing the nutrient content of the high-viscosity meal delayed gastric emptying from 46 ± 9 to 76 ± 6 min (P < 0.004), whereas increasing viscosity had a smaller effect. The volume of secretions within the stomach 60 min after ingestion was higher for the high-viscosity nutrient meal (P < 0.04). A simple model to calculate the total volume of secretion added to the test meal is presented. Color-coded dilution map images showed the heterogeneous process of progressive gastric dilution of high-viscosity meals, whereas low-viscosity meals were uniformly diluted. Fullness was found to be linearly related to total gastric volumes for the nutrient meals (R2 = 0.98) and logarithmically related for the nonnutrient meals (R2 = 0.96). Fullness was higher for high- compared with low-viscosity meals (P < 0.02), and with the nutrient meals this was associated with greater antral volumes (P < 0.05).

stomach; polysaccharide gum; abdominal imaging; echo-planar magnetic resonance imaging


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